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中文摘要：
FADD是TNF受体家族介导的细胞凋亡途径中的接头分子,FADD基因剔除后并未出现预期的淋巴细胞过度增殖，相反表现出T细胞发育和增殖的缺陷现象，成为FADD研究中最大的谜团。申请人定位了FADD磷酸化位点，制备了FADD-/-背景上的转基因FADD(S191D)、FADD(S191A)突变小鼠模型，首次发现FADD C末端的17个氨基酸构成了一个新的结构域，是哺乳动物在进化过程中获得的，191位Ser是其中关键氨基酸。揭示了FADD的一个新的生物功能-细胞增殖，和
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期刊论文
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会议论文
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Polyethylenimie-mediated gene therapy targeting focal adhesion kinase function as melanonoma tumor t
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