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中文摘要：
本项目旨在通过分子设计，合成一系列具有我国自主知识产权的新型肽类树枝状大分子，并对其开展单功能化、双功能化及三功能化的系统性研究，以构筑一个功能化肽类树枝状大分子的研究平台。进而研究靶向基团及寡核苷酸与功能化肽类树枝状大分子的偶联，研究含Gd（III）复合物或超顺磁氧化铁(SPIO)与功能化肽类树枝状大分子的偶联，以期获得可用于寡核苷酸芯片的高特异性生物识别和高灵敏度新型分子探针，及高灵敏度、高靶向效率的MRI 分子探针。研究大分子表面靶向基团密度以及靶向基团与树枝状大分子表面之间手臂分子链长、组成和结构等对靶向效率及显影性能的影响和规律，研究两类分子探针的效能，以及与肽类树枝状大分子及功能团、结构等材料学因素的关系，研究MRI 分子探针的主动靶向效率及在动物体内的动态分布，优化靶向设计。为我国新型生物医学材料的发展开辟一个新的领域，对促进疾病早期临床诊断和治疗，探索疾病的发生和发展做出贡献。
结论摘要：
英文主题词peptide dendrimer; functionization; targeting; molecular probe; molecular diagnosis
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期刊论文
Temperature and pH Double Responsive Hybrid Cross-Linked Micelles Based on P(NIPAAm-co-MPMA)-b-P(DEA
Biotinylated disulfide containing PEI/avidin bioconjugate shows specific enhanced transfection effic
Nanosized Micelles Self-Assembled from amphiphilic dextran-graft-methoxypolyethylene glycol/poly(eps
Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide f
Convenient Preparation of Biodegradable PEI-Containing Polymers as Non-Viral Vectors for Gene Transf
Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro char
Prevention of filtering surgery failure by subconjunctival injection of a novel peptide hydrogel int
Preparation of Novel Ferrocene-Based Shell Cross-Linked Thermoresponsive Hybrid Micelles with Antitu
Inhibition of enhanced green fluorescent protein expression by (dextran-hexamethylenediisocyanate)-g
A Novel Poly(L-glutamic acid) Dendrimer Based Drug Delivery System with Both pH-Sensitive and Target
Multifunctional gadolinium-based dendritic macromolecules: synthesis and application as liver target
Influential factors associated with biotinylated disulfide containing PEI/avidin bioconjugate mediat
Cellular internalization and in vivo tracking of thermosensitive luminescent micelles based on lumin
A facile one-pot construction of supramolecular polymer micelles from alpha-cyclodextrin and poly(ep
The tuned-morphology studies of the complexes between poly(N-isopropylacrylamide)-b-poly(vinylpyridi
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