欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
急性心肌梗死冠脉介入治疗（PCI）后无复流现象（no-reflow）是以冠脉微循环障碍为主要特征的心肌组织失灌注状态，其直接关系到AMI后主要心脏不良事件(MACE)的发生和预后，但是目前缺乏兼有逆转和预防作用的治疗药物。山莨菪碱具有解除微小动脉痉挛、改善微循环灌注和保护缺血心肌的多重药理学效应。本研究在建立小型猪无复流模型的基础上，于PCI术前和术中冠脉内注射山莨菪碱，通过应用冠脉内多普勒流量和压力导丝进行CFR的测定并结合量化冠脉造影-心肌灌注分级（TFCs/TMPG）检测，进行同步实时的评价山莨菪碱冠脉内应用的血流动力学和组织灌注的影响，同时通过检测山莨菪碱对炎症因子的影响，以及随访MACE，探讨其在AMI-PCI病人的综合效应，从而为PCI-No reflow逆转和预防提供一种安全有效的国产药物治疗方法。
结论摘要：
英文主题词intracoronary administration；anisodamine；PCI-noreflow；AMI；mini-pig
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Intensive cholesterol lowering with statin improves the outcomes of percutaneous coronary interventi
Equilibrium radionuclide angiography for evaluating the effect of percutaneous coronary intervention
Comparison of Usefulness of Simvastatin 20 mg Versus 80 mg in Preventing Contrast-Induced Nephropath
会议论文
Comparative study on manipulation and imaging of 4Fr versus 6Fr catheters by transradial coronary an
The effect of preventive intracoronary administration of anisodamine on microcirculation perfusion i
Preventive effects of intracoronary administration of Anisodamine on myocardial microcirculation per
The effect and safety of Tirofiban combined clopidogrel in AMI patients with PCI via transradial app
Effect, safety and feasibility of intracoronary combining administration of anisodamine and tirofiba
A comparative study on manipulation and imaging with 4Fr and 6Fr coronary angiographic catheters via
Clinical Effects and Safety of Delayed PCI combined with Tirofiban in Patients with Acute Myocardial
The effect of intravenous administration of tirofiban on myocardial reflow and left ventricular remo
The Animal Model Establishment of acute coronary no-reflow phenomenon in York swine via intracoronar
Effects of Serum Insulin on Myocardial Microcirculation Perfusion and Cardiac performance for post-P
Effects of no-reflow phenomenon identified by myocardial blush grades on systolic function and synch
A comparative study of facilitated PCI and primary PCI on acute myocardial infarction via transradia
Level change of plasma BNP and the relationships to the left ventricular aneurysm formation and card
The relationship study between BNP levels and CK-MB,cTNI concentrations ,the degree of coronary arte
相关项目
傅向华的项目