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中文摘要：
合成表征了十个三脚架配体和十二个邻菲罗啉桥联多胺配体，利用pH法研究其及其配合物的热力学性质，利用31PNMR和EPR对其作为ATP水解酶模型物进行了热力学性质研究，给出了催化ATP水解的超分子体系模型。利用31PNMR进行了上述配体与"软"，"硬"酸所形成的配合物作为催化剂 水解ATP的研究。发现金属离子在ATP水解反应中充当"信使"起了一个调控作用。首次发现在不同的反应途径中水在不同的阶段参与水解反应，且所起的作用亦不相同。从大肠杆菌中提取了质粒DNApUC19,然后用邻菲罗啉桥联多胺配体及其配合物进行DNA水解反应，通过电泳实验发现这些模拟物能很好地水解DNA.并进行了上述模拟物对大肠杆菌生长速率的影响研究。讨论了配体及其配合物能不同加速DNA裂解的内在原因。
结论摘要：
英文主题词ATP, DNA, hydrolysis reaction ,
成果综合统计
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期刊论文
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