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光化学
  • 项目名称：光化学
  • 项目类别：国家杰出青年科学基金
  • 批准号：20725308
  • 申请代码：B0307
  • 项目来源：国家自然科学基金
  • 研究期限：2008-01-01-2011-12-31
  • 项目负责人：王树
  • 负责人职称：研究员
  • 依托单位：中国科学院化学研究所
  • 批准年度：2007
中文摘要：

共轭聚合物具有强的光捕获能力，可用来放大荧光传感信号。我们立足化学与生物学学科交叉前沿，围绕共轭聚合物荧光探针设计、传感机制和光物理过程，设计合成了系列新型水溶性共轭聚合物荧光探针，建立和发展了多种高灵敏度检测新方法，探索了共轭聚合物在重大疾病早期诊断和治疗中的新应用通过荧光共振能量转移技术，发展了 DNA甲基化水平检测的新方法，研究了结肠癌病人样品基因启动子区特异CpG位点的甲基化状态；构建了阳离子共轭聚合物/DNA自组装体系，通过控制能量转移过程，实现了对DNA单核苷酸多态性的灵敏检测；通过控制多重能量转移过程实现了多种核酸酶的同时检测；发展了以蛋白酶、核酸酶、RNA－蛋白质复合物为靶点的药物筛选新体系；设计合成了系列共轭聚合物抗肿瘤与成像多功能体系，实现了对肿瘤细胞、细胞凋亡的高灵敏荧光成像以及高效抗肿瘤活性。这些研究成果为共轭聚合物在重大疾病早期诊断与治疗领域的实际应用打下了坚实的基础。

中文主题词： 共轭聚合物；光物理；生物大分子；生物识别；生物传感
结论摘要：

英文主题词conjugated polymers; biosensors; DNA; protein

成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 49
  • 12
  • 0
  • 0
  • 0
期刊论文
An optical approach for drug screening based on light-harvesting conjugated polyelectrolytes
Lipid-modified conjugated polymer nanoparticles for cell imaging and transfection
Synthesis of new zwitterionic water-soluble oligofluorenes with good light-harvesting ability
Water-soluble fluorescent conjugated polymers and their interactions with biomacromolecules for sens
A new water-soluble conjugated polymer for protein identification and denaturation detection
Conjugated polymers as multifunctional biomedical platforms: anticancer activity and apoptosis imagi
DNA-templated synthesis of cationic poly(34-rthylenedioxythiophene) derivative for supercapacitor el
Conjugated polymer nanoparticles for drug delivery and imaging
Water-soluble conjugated polymers for fluorescent enzyme assays
Synthesis and characterization of degradable water-soluble fluorescent polymers
Gadolinium (III) chelated conjugated polymer as a potential MRI contrast agent
Cationic Conjugated Polymers for Optical Detection of DNA Methylation Lesions and Single Nucleotide
Assemblies of conjugated polyelectrolytes with proteins for controlled protein photoinactivation
A new light-harvesting conjugated polyelectrolyte microgel for DNA and enzyme detections
Label-free homogeneous and fluorescence "turn-on" detection of protease using conjugated p
Conjugated polyelectrolytes as new platforms for drug screening
Homogeneous and one-step fluorescent allele-specific PCR for SNP genotyping assays using conjugated
Fluorescent logic signal-based multiplex detection of nucleases with the assembly of cationic conjug
Conjugated polymer/porphyrin complexes for efficient energy transfer and improving light-activated a
Water-soluble conjugated polyelectrolyte-based fluorescence enzyme coupling protocol for continuous
An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug res
Synthesis of amphiphilic polythiophene for Cell imaging and monitoring cellular distribution of cisp
Design guidelines for conjugated polymers with light-activated anticancer activity
Tetraacenaphthoporphyrin: A pi-conjugated porphyrin with efficient light-activiated anticancer activ
Development of film sensors based on conjugated polymers for copper (II) ion detection
Conjugated polyelectrolytes for label-free DNA microarrays
Conjugated polyelectrolytes for protein assay and manipulation of catalytic activity of enzyme
Synthesis of a new water-soluble oligo(phenylenevinylene) containing tyrosine moiety for tyrosinase
Fluorescent conjugated polyelectrolyte as an indicator for convenient detection of DNA methylation
Direct visualization of glucose phosphorylation with a cationic polythiophene
A conjugated polymers-based electrochemical DNA sensor: design and application of a multi-functional
Microorganism-based assemblies of luminescent conjugated polyelectrolytes
高灵敏共轭聚合物化学传感器
水溶性聚芴衍生物的合成、性质与生物检测应用
会议论文
Conjugated Polyelectrolytes for Fluorescent Assays of DNA and Enzyme
Conjugated Polyelectrolytes as Platforms for Biomacromolecules Detections
Conjugated Polyelectrolytes for Fluorescent Assays of DNA and Enzyme
Fluorometric Assays for DNA and protein with Conjugated Polyelectrolytes
共轭聚合物的生物识别与传感研究
Conjugated polyelectrolytes as new optical probes for biosensing and imaging
Conjugated polymer-based fluorescence resonance energy transfer technique for biosensing and cell im
Conjugated Polyelectrolyte as new optical probes for biomacromolecular detections
Conjugated Polyelectrolyte Probes for Biomacromolecular Detection, , September 13-16, 2009
Conjugated Polyelectrolytes as Platforms for Biomacromolecule
Conjugated polyelectrolytes for biosensing and imaging
Conjugated polymer-based fluorescence resonance energy transfer technique for biosensing and cell im
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