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中文摘要：
针对小分子探针和基于聚合物本体性质的传感器研究中存在的问题和实际应用局限性，本项目致力于发展基于响应性聚合物的化学与生物传感器这一新方向。利用响应性聚合物对特定刺激信号产生非线性响应和自组织行为的特性，通过超分子识别和化学反应触发特殊设计功能基团的光学信号发生显著变化，基于响应性聚合物的可逆链构象变化、可控聚集和组装行为有效调控识别基元和光学检测基元的空间分布，结合触发式自分解聚合物、电荷反转聚合物、荧光疏水增强等概念和磷光、化学发光、光致变色、荧光共振能量转移 (FRET) 等光物理过程，融入荧光信号的化学放大、物理放大以及循环放大等新颖策略，实现检测性能的优化和检测功能的协同与集成，提高化学和生物检测体系的选择性与灵敏度。在该方向的系统和深入研究有助于掌握响应性聚合物在不同条件下对各类检测模块的影响规律，预期能为探索和发展响应性聚合物在功能材料和器件等方面的应用开辟一条崭新的途径。
英文摘要：
Responsive Polymers；Chemosensors and Biosensors；Biomaterials；Drug Nanocarriers；Theranostic Systems
结论摘要：
针对小分子探针和基于聚合物本体性质的传感器研究中存在的问题和实际应用局限性，本项目致力于发展基于响应性聚合物的化学与生物传感器这一新方向。利用响应性聚合物对特定刺激信号产生非线性响应和自组织行为的特性，通过超分子识别和化学反应触发特殊设计功能基团的光学信号发生显著变化，基于响应性聚合物的可逆链构象变化、可控聚集和组装行为有效调控识别基元和光学检测基元的空间分布，结合触发式自分解聚合物、电荷反转聚合物、荧光疏水增强等概念和磷光、化学发光、光致变色、荧光共振能量转移 (FRET) 等光物理过程，融入荧光信号的化学放大、物理放大以及循环放大等新颖策略，实现检测性能的优化和检测功能的协同与集成，提高化学和生物检测体系的选择性与灵敏度。项目执行期间，在基于响应性高分子组装体和纳米粒子的可控制备，性能调控和功能拓展方面开展了较为系统的工作。提出了“电荷生成聚合物 (Charge-Generation Polymers, CGPs)”, “聚前药两亲性分子 (Polyprodrug Amphiphiles)”, 超支化聚前药两亲分子(Hyperbranched Polyprodrug Amphiphiles, hPAs), 触发式自降解囊泡 (Self- Immolative Polymersomes, SIPsomes), Traceless Crosslinking用于同步交联和渗透性调控等新概念和新策略; 发展了具有独特拓扑结构的触发式自降解聚合物; 以高分子设计合成和可控多级自组装为基础，在功能拓展方面聚焦于对病变部位微环境具有灵敏响应和反馈的高分子和超分子体系构建，发展了多类独具特色的响应性高分子药物纳米载体、高灵敏度和选择性检测体系和成像/诊疗一体化体系，提出了几种设计新思路与新路线，部分研究成果已受到国际同行的关注，并有后续跟踪研究。在该方向的系统和深入研究的基础上，掌握了响应性聚合物在不同条件下对各类检测模块的影响规律，预期将为探索和发展响应性聚合物在生物功能材料和器件等方面的应用开辟一条崭新的途径。
成果综合统计
期刊论文
会议论文
专利
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著作
期刊论文
Spatiotemporal Monitoring Endocytic and Cytosolic pH Gradients with Endosomal Escaping pH-Responsive
Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reaction
Responsive polymer-based multicolor fluorescent probes for temperature and Zn2+ ions in aqueous medi
Fabrication of Thermoresponsive Cross-Linked Poly(N-isopropylacrylamide) Nanocapsules and Silver Nan
Construction of Polymer-Protein Bioconjugates with Varying Chain Topologies: Polymer Molecular Weigh
Highly Selective Colorimetric and Fluorometric Probes for Fluoride Ions Based on Nitrobenzofurazan-c
pH-Disintegrable Polyelectrolyte Multilayer-Coated Mesoporous Silica Nanoparticles Exhibiting Trigge
Glucose-Regulated Insulin Release from Acid-Disintegrable Microgels Covalently Immobilized with Gluc
Thermo-and light-regulated fluorescence resonance energy transfer processes within dually responsive
Stimuli-responsive tertiary amine methacrylate-based block copolymers: Synthesis, supramolecular sel
Engineering FRET processes within synthetic polymers, polymeric assemblies and nanoparticles via mod
Supramolecular Assembly-Assisted Synthesis of Responsive Polymeric Materials with Controlled Chain T
Drug-Loaded and Superparamagnetic Iron Oxide Nanoparticle Surface-Embedded Amphiphilic Block Copolym
Kinetics of thermo-induced micelle-to-vesicle transitions in a catanionic surfactant system investig
Thermogelling of Double Hydrophilic Multiblock and Triblock Copolymers of N,N-Dimethylacrylamide and
Stimuli-Triggered Off/On Switchable Complexation between a Novel Type of Charge-Generation Polymer (
Reactive Fluorescence Turn-On Probes for Fluoride Ions in Purely Aqueous Media Fabricated from Funct
Ultrasensitive ratiometric fluorescent pH and temperature probes constructed from dye-labeled thermo
Polymeric assemblies and nanoparticles with stimuli-responsive fluorescence emission characteristics
Photo-Degradable, ProteinPolyelectrolyte Complex-Coated, Mesoporous Silica Nanoparticles for Control
Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli-Regulat
Fluorescent water-soluble responsive polymers site-specifically labeled with FRET dyes possessing pH
Responsive Polymers-Based Dual Fluorescent Chemosensors for Zn2+ Ions and Temperatures Working in Pu
Asymmetrically functionalized beta-cyclodextrin-based star copolymers for integrated gene delivery a
Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Dr
Construction of Polyelectrolyte-Responsive Microgels, and Polyelectrolyte Concentration and Chain Le
Cytosol-Specific Fluorogenic Reactions for Visualizing Intracellular Disintegration of Responsive Po
Rationally Engineering Phototherapy Modules of Eosin-Conjugated Responsive Polymeric Nanocarriers vi
Highly sensitive and selective fluorometric off-on K+ probe constructed via host-guest molecular rec
Amphiphilic Star Copolymer-Based Bimodal Fluorogenic/Magnetic Resonance Probes for Concomitant Bacte
Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and A
PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block c
Drug and plasmid DNA co-delivery nanocarriers based on abctype polypeptide hybrid miktoarm star copo
Thermo- and Light-Regulated Formation and Disintegration of Double Hydrophilic Block Copolymer Assem
Mixed polymeric micelles as multifunctional scaffold for combined magnetic resonance imaging contras
Selectively grafting polymer from the interior and/or exterior surfaces of bioreducible and temperat
Recent advances towards the fabrication and biomedical applications of responsive polymeric assembli
Composite silica nanospheres covalently anchored with gold nanoparticles at the outer periphery of t
Multifunctional pH-Disintegrable micellar nanoparticles of asymmetrically functionalized beta-cyclod
Polyion complex micellar nanoparticles for integrated fluorometric detection and bacteria inhibition
Stimuli-Responsive Fluorescent Poly(N-isopropylacrylamide) Microgels Labeled with Phenylboronic Acid
Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for si
Schizophrenic Core-Shell Microgels: Thermoregulated Core and Shell Swelling/Collapse by Combining UC
Stopped-flow kinetic studies of the formation and disintegration of polyion complex micelles in aque
Two-Photon Ratiometric Fluorescent Mapping of Intracellular Transport Pathways of pH-Responsive Bloc
会议论文
Unique thermo-induced sequential gel-sol-gel transition of responsive multiblock copolymer-based hyd
Well-Defined Biocompatible ABC Miktoarm Star Polypeptide Hybrid Terpolymers for Drug and Gene Co-Del
Efficient Synthesis of Janus-Type Gold Nanoparticle Hybrid Amphiphilic Triblock Copolymers and Their
Caged Polyelectrolytes: Stimuli-Triggerable Charge-Generation Polymers (CGPs) and Functional Materia
Caged Polyelectrolytes: Stimuli-Triggered Charge-Generation Polymers (CGPs) and Functional Materials
Efficient Synthesis of Janus-Type Gold Nanoparticle Hybrid Amphiphilic Triblock Copolymers and Their
Caged Polyelectrolytes: Stimuli-Triggered Charge-Generation Polymers (CGPs) and Functional Materials
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