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中文摘要：
申请人长期从事纳米生物材料的合成及其在靶向给药系统、组织修复中的应用基础研究，合成了两亲性嵌段共聚物，采用自组装纳米技术提高了紫杉醇、和厚朴酚等多种难溶药物的水溶性、降低了药物毒副作用，且避免使用有毒的有机溶剂和表面活性剂；合成了安全、转染效率高的可降解聚乙烯亚胺衍生物作为基因治疗传递载体；合成了可降解温敏水凝胶，发现其在预防术后组织粘连及促进组织修复方面具有很好的效果。在ACS Nano, Pharm Res等期刊发表SCI论文76篇，SCI他引376次。任SCI期刊J Biomedical Nanotechnology亚洲主编、Advanced Science Letters副主编。获得了教育部新世纪人才、四川省杰出青年科技基金支持。本项目拟在前期工作基础上制备新型肿瘤靶向的聚乙烯亚胺衍生物，采用自组装技术与pVSVMP质粒形成纳米复合物，建立结肠癌的肺转移模型，考察抗肿瘤效果和机制。
结论摘要：
英文主题词nanobiomaterials；biomedical materials；nanomedicine；nanobiotechnology；pharmaceutics
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期刊论文
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