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中文摘要：
利用生物催化剂实现的芳香硝基以及刚性大环芳香酮的选择性还原具有效率高，选择性强，条件温和及环境友好等优势。项目组对14种植物提取物评价，发现葡萄催化转化芳香硝基生成相应羟胺氨产物比例为955，具有高度的选择性，且转化率大于99%；另外，葡萄在不对称还原取代芴酮时也表现优异，转化率为>99%， ee>99%；同时证实该催化过程是非酶催化。另外，项目组也成功筛选到一株能高效还原芳香硝基和芳香酮的链霉菌Streptomyces sp. YX001,并成功分离获得其中的芳香硝基还原酶及其N-端氨基酸序列。以上成果为制备具有重要应用价值的芳香硝基和酮基化合物还原产物提供了新的方法和思路，同时也增进了对生物催化剂的了解。
结论摘要：
英文主题词nitroreductase;ketone oxidase; plant; Streptomyces;selectivity
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