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中文摘要：
本项目通过分子识别、纳米组装、器件集成、系统构建、生物信息分析等方面的研究，以实现生物信息的高通量快速检测和生物体的系统分析。本项目取得的主要成果有（1）提出了一种基于软光刻技术的高密度寡核苷酸微阵列芯片的制备技术，制备出集成度为64K的高密度微阵列芯片，具有单个碱基错配的识别能力。（2）发展一种新的高通量低成本DNA测序的试剂和方法，初步完成了DNA高通量测序的样机，在测序速度、成本和模板制备的偏向性等方面均有一定优势。（3）建立了若干新的可用于基因组功能研究的微阵列生物芯片平台，包括可用于大量样本检测的SNP微阵列芯片筛选平台、用于DNA结合蛋白检测的双链DNA微阵列芯片、以及用于DNA甲基化谱图检测的DNA微阵列芯片，并成功地运用于大量临床样品的分析。（4）发展了与生物芯片相关的生物信息学工具，建立了有一定影响的新算法、数据库、分析软件。（5）发展了若干可用于临床分析检测的新型生物信息检测技术和器件。包括基于光子晶体的液相芯片、高通量免疫细胞检测芯片、全封闭管盖型微阵列芯片、定量PCR微阵列芯片。
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期刊论文
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期刊论文
Evaluating the binding affinities of NF-kB P50 homodimer to the wild-type and single-nucleotide muta
Microarray-based approach for high-throughput genotyping of single nucleotide polymorphisms with lay
The relationship between synonymous codon usage and protein structure in Escherichia coli and Homo s
Hydrolysis of microporous polyamide-6 membranes as substrate for in situ synthesis of oligonucleotid
Determination of trace amount of bismuth(II) by adsorptive anodie stripping voltammetry at carbon pa
DNA microarrays with unimolecular hairpin double-stranded DNA probes: fabrication and exploration of
Fabricating Unimolecular Double-stranded DNA Microarray on solid surface for probing DNA-protein/dru
Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-colo
Mapping nanoscale domains in a sol-gel-derived(Pb,La)(Zr,Ti)O3 thin film using atomic force microsco
Accurate identification of closely related Dendrobium species with multiple species-specific gDNA pr
Detection of p16 hypermethylation in gastric carcinomas using a semi-nested methylation-specific PCR
Microarray-based method to detect methylation changes of p16Ink4a gene 5’-CpG islands in gastric car
Visible-light responsive cerium ion modified titania sol and nanocrystallites for X-3B dye photodegr
A novel substrate for in situ synthesis of oligonucleotide: plasma-treated polypropylene microporous
A solid Ag film deposited from solution on self-assembled mercaptopropyltrimethoxysilane(MPTS) onola
Acidity of calcined Al,Fe and La-containing MCM-41 mesoporous materials: an investigation of adsorpt
Detection of methylation of human p16Ink4a gene 5’-CpG islands by electrochemical method coupled wit
会议论文
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