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中文摘要：
本团队的核心成员为5名入选中科院"百人计划"的优秀学者和一名院士，是中国科学院"病原微生物与免疫学"院重点实验室的科研主力。在田波院士带领下，由高福博士组建本团队，逐渐形成了一个在病原微生物与宿主互作研究领域的研究群体。各成员之间长期合作，共同承担多项科研项目，并联合发表多篇论文，在动物源性病原微生物分子进化和跨种间传播机制，病毒融合机制，以及病原微生物与宿主互作中宿主限制性因子对病毒复制的调控、病原微生物的抗原加工与T细胞识别等方面做出了特色，在Science, Lancet, PNAS, PLoS Medicine，JI,JID，CM，JBC，EJI等发表多篇论文。团队将聚焦动物源性病原跨种间传播机制、宿主限制性因子和抗原加工、T细胞识别机制等开展基础研究，推动相关产业的技术发展。
英文摘要：
pathogens；interspecies transmission；cellular immune；influenza virus；
结论摘要：
研究群体的任务书中的研究目标是开展动物源性病原微生物跨种间传播机制和细胞免疫分子互作等两方面的研究，主要围绕宿主限制性因子，分子进化与病毒与宿主因子之间的相互作用，以及病原微生物抗原加工与提呈的基础研究、重大传染病特异性细胞免疫调控、细胞免疫重要蛋白的结构免疫学等开展工作，研究群体经过三年的努力已经实现科学目标。主要开展了以下3方面研究流感等动物源性病毒分子进化、跨种传播机制以及病毒侵染和释放机制；流感、风疹、乙肝等囊膜病毒与宿主互作及宿主限制性因子研究；囊膜病毒“剥削”宿主免疫细胞为己用的机制及细胞免疫调控。 课题组围绕流感、乙肝等囊膜病毒与宿主之间的互作和宿主因子开展系统研究，在动物源性病毒跨种传播机制、囊膜病毒受体识别和宿主限制性因子等研究在国际上形成了自己的特色。研究成果在Nature, Science, Lancet, Nature Communications, Nature Structural and Molecular Biology, Hepatology, PNAS等杂志共发表论文124篇，其中影响因子5以上的论文47篇，影响因子8以上论文12篇。申请国家发明专利5项，专利授权9项。 在平台建设方面，建成了一个病原微生物研究关键技术平台，生物安全三级（BSL-3）实验室，建立了T细胞检测平台并对外开展服务，研发成功基于细胞免疫原理的新型结核诊断ELISPOT检测试剂盒, 并与北京佑安医院、北京302医院、北京309医院、北京朝阳医院等北京主要传染病医院开展长期合作。
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期刊论文
A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous pro
Crystal Structure of Swine Major Histocompatibility Complex Class I SLA-1*0401 and Identification of
Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1
Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restr
Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with
Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3
Heat Shock Protein 70 Inhibits the Activity of Influenza A Virus Ribonucleoprotein and Blocks the Re
Phosphorylation of Minichromosome Maintenance Protein 7 (MCM7) by Cyclin/Cyclin-dependent Kinase Aff
Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cell
Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and
Hansenula polymorpha expressed heat shock protein gp96 exerts potent T cell activation activity as a
Identification of novel virus inhibitors by influenza A virus specific reporter cell based screening
Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza vir
Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative mod
Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lym
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen R
The Differential Antiviral Activities of Chicken Interferon alpha (ChIFN-alpha) and ChIFN-beta are R
Heat shock protein gp96 enhances humoral and T cell responses, decreases Treg frequency and potentia
Revival of the identification of cytotoxic T-lymphocyte epitopes for immunological diagnosis, therap
A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic island
Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Re
Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory rece
Reply to "Nuclear Export Signal and Immunodominant CD8(+) T Cell Epitope in Influenza A Virus Matrix
The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strai
Novel Plasmid and Its Variant Harboring both a bla(NDM-l) Gene and Type IV Secretion System in Clini
Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Im
Type-IVC Secretion System: A Novel Subclass of Type IV Secretion System (T4SS) Common Existing in Gr
LILRA3 Binds Both Classical and Non-Classical HLA Class I Molecules but with Reduced Affinities Comp
An infectious clone of the highly pathogenic porcine reproductive and respiratory syndrome virus: To
Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Ha
Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA
Cyclophilin E Functions as a Negative Regulator to Influenza Virus Replication by Impairing the Form
Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific M
Mechanisms and Therapeutic Strategies of Chronic Infection and Inflammation-Associated Hepatocellula
Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemag
Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Li
Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibi
Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor
Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian p
A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-l
Enterovirus 71 VP1 Activates Calmodulin-Dependent Protein Kinase II and Results in the Rearrangement
Inhibition of Atrogin-1/MAFbx Expression by Adenovirus-Delivered Small Hairpin RNAs Attenuates Muscl
Polo-Like Kinase 1 Inhibits the Activity of Positive Transcription Elongation Factor of RNA Pol II b
An unexpected similarity between antibiotic-resistant NDM-1 and beta-lactamase II from Erythrobacter
Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influ
VP2 Dominated CD4(+) T Cell Responses against Enterovirus 71 and Cross-Reactivity against Coxsackiev
Two Distinct Conformations of a Rinderpest Virus Epitope Presented by Bovine Major Histocompatibilit
Transport of Influenza Virus Neuraminidase (NA) to Host Cell Surface Is Regulated by ARHGAP21 and Cd
Increased Expression of Gp96 by HBx-Induced NF-kappa B Activation Feedback Enhances Hepatitis B Viru
MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic
Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into t
Gp96 enhances the immunogenicity of subunit vaccine of porcine reproductive and respiratory syndrome
Tyrosine 132 Phosphorylation of Influenza A Virus M1 Protein Is Crucial for Virus Replication by Con
Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific s
Identification and Characterization of Three Novel Nuclear Export Signals in the Influenza A Virus N
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