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中文摘要：
新辅助化疗可增大进展期胃癌患者获得根治性切除的机会。目前影像学缺乏有效评价胃癌新辅助化疗疗效的客观手段。本项目拟优化胃癌磁共振多b值扩散加权成像序列参数设置，完善成像技术流程，在此基础上构建反映胃癌组织水分子扩散变化的高斯模型（单指数模型）与非高斯模型（双指数模型和FROC模型）。通过影像病理对照研究，明确各模型参数与微血管密度、细胞密度和组织均匀度的相关性，探索其变化的病理组织学机制，提取能够有效反映胃癌生物学行为特征及新辅助化疗疗效的定量参数。进而通过与术后病理退缩分级及无瘤生存期和生存时间的对照分析，确定磁共振扩散加权成像各模型参数评价胃癌新辅助化疗疗效的阈值和早期敏感时间窗。本项目的目标在于探索一种无创、定量、经济及可重复的早期预测胃癌新辅助化疗效果的方法，为胃癌新辅助化疗个体化的实现提供理论和实践依据。
结论摘要：
英文主题词gastric cancer；gastrointestinal stromal tumor；magnetic resonance imaging；diffusion weighted；response evaluation
成果综合统计
期刊论文
会议论文
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期刊论文
Fused monochromatic imaging acquired by single source dual energy CT in hepatocellular carcinoma dur
Applicable apparent diffusion coefficient of an orthotopic mouse model of gastric cancer by improved
Diffusion-weighted magnetic resonance imaging in the depiction of gastric cancer: initial experience
会议论文
Predicting Response in Gastrointestinal Stromal Tumor to Sunitinib Second-line Therapy Using Non-Gau
Diffusion-weighted magnetic resonance imaging in the depiction of gastric cancer: initial experience
Region-by-region comparison of CT missed peritoneal metastasis with diagnostic laparoscopy in gastri
The Correlation of Iodine Concentration in Spectral CT and Pathological Regression in Gastric Cancer
A new sandwich sign of Borrmann type 4 gastric cancer on diffusion-weighted MRI: radiological-histop
A new sandwich sign of Borrmann type 4 gastric cancer on diffusion-weighted MRI: radiological-histop
A new sandwich sign of Borrmann type 4 gastric cancer on diffusion-weighted MRI: radiological-histop
Dynamic-energy-adjustment of spectral CT in the demonstration of subtle structures: a comparison stu
A new sandwich sign of Borrmann type 4 gastric cancer on diffusion-weighted MRI: radiological-histop
Correlation of diffusion weighted MR imaging with the prognosis of locally advanced gastric adenocar
MRI in the response prediction of gastrointestinal stromal tumor to targeted therapy: a patient-base
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