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中文摘要：
肿瘤标志物的检测对恶性肿瘤的早期诊断和治疗都有非常重要的意义，高灵敏、高特异、多组分、高通量的肿瘤标志物分析技术仍是科学家们的重要研究兴趣。核酸适体由于其亲和力高、特异性强、靶分子广、易于体外合成与修饰等特点，正逐渐取代抗体成为肿瘤标志物分析的重要探针分子。但目前已报道的基于核酸适体的肿瘤标志物分析策略绝大多数仅限于检测一种肿瘤标志物，不利于相关肿瘤的确诊。另外，由于核酸适体探针和其目标分子的结合常数相对较低，传统的传感策略还很难获得较高的检测灵敏度。为了解决这些问题，本项目拟通过巧妙设计多功能化的核酸适体探针以达到可以平行或者同时检测多种肿瘤标志物的目的，并且借助等温循环链置换聚合信号放大技术，实现对肿瘤标志物目标分子的高灵敏检测。通过对多种肿瘤标志物的高灵敏、联合分析为恶性肿瘤的早期准确诊断提供重要的方法指导及理论基础。
结论摘要：
英文主题词aptamer；isothermal circular strand displacement polymeriza；tool enzyme；tumor marker；
成果综合统计
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期刊论文
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One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analy
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