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中文摘要：
糖在生物体内的功能越来越被人们所认识，然而糖科学发展的瓶颈之一是糖链合成的困难。本项目针对寡糖合成中的关键问题，利用项目组已取得的大量前期工作基础，包括不依赖于糖模块活性的预活化的一釜寡糖合成策略，以寡糖的高效合成或自动化合成为导向，计划开展以下内容的研究1）糖基化反应基本问题的研究；2）寡糖组装策略的发展和完善；3）新方法、新策略在具有重要生物活性和潜在药用价值的复杂寡糖合成方面的应用。本项目的实施将促进我国糖化学研究的发展，并为糖生物学和糖类药物的研究提供强有力的工具。
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期刊论文
Enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of ST
O,O-Dimethylthiophosphonosulfenyl Bromide-Silver Triflate: A New Powerful Promoter System for the Pr
Synthesis and Crystal structure of (1R,2S,3S,4S)-(6-O-acetyl-1,2-O-isoproplidene-3,5-dideoxy-(-D-glu
Synthesis of allyl 4-O-{3-deoxy-3-[4-benzylaminocarbonyl-1H-(1, 2, 3)-triazol-1-yl]-(-galactopyranps
Additive-Controlled Stereoselective Glycosylations of Oxazolidinone Protected Glucosamine and Galact
A Highly α-Stereoselective Synthesis of Oligosaccharide Fragments of Vi Antigen from Salmonella typh
Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synt
The (-directing effect of ionic liquid in mannopyranosylation: a potential access to stereoselective
Direct α-Selective Glycosylations of Acetyl-Protected 2-Deoxy and 2,6-Dideoxythioglycosides by Preac
A Highly Efficient and Mild Method for Regioselective de-O-benzylation of Saccharides by Co2(CO)8-Et
Regio- and Stereo-Selective Synthesis of Aryl 2-Deoxy-C-Glycopyranosides by Palladium-Catalyzed Heck
Stereoselectivity investigation on glycosylation of oxazolidinone protected 2-amino-2-deoxy-D-glucos
Efficient synthesis of a series of novel fructose-based 3-acetyl-5-alkyl-2, 3-dihydro- 1,3,4-oxadiaz
A highly α-selective glycosylation for the convenient synthesis of repeating α-1→4 linked N-acetyl-g
Stereoselective Synthesis of 2-Deoxy-Pyranosides via the Lewis Acid-Promoted Rearrangement of 2,3-An
Bromodimethylsulfonium bromide-silver triflate: a new powerful promoter system for the activation of
Highly Direct α-Selective Glycosylations of 3,4-O-Carbonate-Protected 2-Deoxy and 2,6-Dideoxythiogly
Microwave-assisted efficient synthesis of glucose-based 3-acetyl-5-alkyl-2, 3-dihydro-1, 3, 4-oxadia
NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide br
Synthesis of stryphnoside A, a triterpene saponin isolated from the pericarps of Stryphnodendron fis
Crystal Structures of Streptococcus suis Mannonate Dehydratase (ManD) and Its Complex with Substrate
Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidi
Efficient and selective removal of chloroacetyl group promoted with tetra-n-butylammonium fluoride (
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