中文摘要：

目的：通过对原头蚴的荧光成像,鉴定不同药物处理后原头蚴的活性。并为小鼠体内的细粒棘球蚴荧光模型奠定实验基础。方法：通过JC-1染色监测体外实验中的原头蚴。结果：不同药物处理组的原头蚴,可以根据红/绿荧光强度比量化分析标记后原头蚴的活性;二甲双胍处理后的原头蚴活性下降,联合用药后,原头蚴的活性最低。结论：二甲双胍具有一定的抗包虫作用;红/绿荧光强度比越大,原头蚴的活性越强。

英文摘要：

Objective： Through the fluorescence imaging of Echinococcus granulosus,activity of protoscoleces was identified after different treatments,and the experimental basis was provided for the constructionn of Echinococcus granulosus fluorescence mice model.Methods：In vitro monitoring in protoscoleces by JC-1 staining.Results：The activity of protoscoleces in different drug-treated groups,could be quantitative analysed by the ratio of red and green fluorescence intensity.Protoscoleces activity was decreased after the treatment of metformin;the activity of protoscoleces was the lowest after combined medication.Conclusion：Metformin has certain anti-echinococcal effects,and the greater of ratio of red and green fluorescence intensity results in the higher activity of protoscoleces.