中文摘要：

目的：探讨不同类型肝囊型包虫病（CE）患者外周血中白细胞介素-17（IL-17）、白细胞介素-10（IL-10）在疾病发展过程中的作用及对囊肿生物活性判断的价值。方法：将33例CE患者和21例健康体检者按WHO的囊型包虫病B超分类原则共分为4组：健康对照组21例，I、Ⅱ型包虫病组14例，Ⅲ型包虫病组10例，Ⅳ、V型包虫病组9例。采用酶联免疫吸附法（ELISA法）检测各组IL-17、IL-10的表达。结果：Ⅲ型包虫病组IL-17水平显著高于其他各型包虫病组，差异有统计学意义（P〈0．05）；I、Ⅱ型包虫病组IL-17水平[（38．57±3．83）pg／mL]与Ⅳ、V型包虫病组[（40．22±5．15）pg／mL]比较无明显差异。Ⅲ型包虫病组IL-10水平[（14．65±2．15）pg／mL]显著高于I、Ⅱ型包虫病组[（11．38±0．71）pg／mL]，I、Ⅱ型包虫病组IL-10水平显著高于Ⅳ、V型包虫病组[（7．60±0．46）pg／mL]，差异有统计学意义（P〈0．05）；I、Ⅱ型包虫病组IL-17／IL．10（3．44±1．04）与Ⅲ型包虫病组（4．60±2．40）相比较无明显差异，Ⅲ型包虫病组IL-17／IL-10与Ⅳ、V型包虫病组（5．39±1．95）相比较无明显差异，I、Ⅱ型包虫病组IL-17／IL-10显著低于Ⅳ、V型包虫病组（P〈0．05）。结论：IL-17、IL-10相互协同在促进CE自然病程发展中可能起到一定作用．IL-17和IL-10不能单独作为判断包虫囊肿活性的指标：IL-17／IL．10在-定程度上反应了包虫囊肿的活性．但作为判断各型肝囊型包虫囊肿的活性指标有待进-步讨论验证。

英文摘要：

Objective To explore the significance of IL-17 and IL-10 in patients with different types of hepatic cystic echinococeosis （CE） in cyst stages, to investigate the values of evaluation of hydatid cyst activity. Methods 33 patients with hepatic hydatid disease and 21 heahhy people （control group） were enrolled, divided into 4 groups, according to WHO uhrasonic classification for CE： Control group （n = 21）, CE I ,II group （active, n = 14）, CE III group （transitional, n = 10）, and CE IV, Vgroup （inactive, n = 9）. The serum concentrations of IL- 17 and IL-10 were measured by enzyme-linked immunosorbent assay. Results Serum levels of IL-17 in CE III group were significantly higher than other groups （P 〈 0.05）. There were no significant difference in serum IL-17 levels between CE I, II group [（38.57 ± 3.83） pg/mL] and CE IV, V group [（40.22 ± 5.15） pg/mL]. Serum levels of IL- 10 were significantly higher in CE III group [ （14.65 ＋ 2.15） pg/mL] than CE I, II group [ （ 11.38 ± 0.71） pg/mL] （P 〈 0.05）, while CE I , II group were significantly higher than CE IV, V group [ （7.60 ± 0.46） pg/mL] （P 〈 0.05）. There were no significant difference of IL-17/IL-10 ratio between CE I , 11 group （3.44 ± 1.04） and CE m group （4.60 ±＋ 2.40）, and there were no significant difference of IL-17/IL-10 ratio between CE III group and CE IV, Vgroup （5.39±1.95）. IL-17/IL-10ratioin CE I, II group was siguificantly lower than CE IV , Vgroup （P〈0.05）. The serum concentrations of IL-17 has no correlation with IL-10 in different cyst stages. Conclusions The synergy effect of IL-17 and IL-10 may play the certain role to promote the parasite progress. Neither IL-17 nor IL-10 level could be as an independent marker of echinococeal cysts activity, while IL-17/IL-10 ratio reflect the hydatid cyst activity in certain degree, but as a echinococcal cysts activity marker, further evidence should be needed.