中文摘要：

细胞因子信号转导抑制分子（suppressor of cytokine signaling,SOCS）是一类在细胞信号转导过程中发挥重要作用的负调控因子,家族成员一共有8个,主要通过抑制JAK-STAT信号通路的持续激活而调节细胞的增殖、分化和凋亡。在肿瘤的发生发展过程中,由于SOCS家族基因启动子区CG岛超甲基化、组蛋白异常乙酰化、基因突变、基因缺失等原因导致的SOCS蛋白表达异常,使JAK-STAT被持续活化,从而导致肿瘤的发生发展与转移。本文综述了SOCS家族的发现,成员构成及分子结构,各结构域的功能及其在肿瘤发生发展等方面的最新进展。由于SOCS在肿瘤发生、发展方面的重要作用,SOCS分子作为信号转导途径重要的负调节因子发挥肿瘤抑制作用,使其成为肿瘤治疗的新靶标。

英文摘要：

Suppressor of cytokine signaling （SOCS） family proteins are a group of negative regulatory factors that plays important roles in the negative regulation of cytokine responses by terminating the activation of the JAK-STAT and other signaling pathways. hTe family is composed of eight structurally related proteins. mainly through the inhibition of the activation of JAK-STAT signaling pathway and regulates cell proliferation, differentiation and apoptosis. In the process of tumor progres-sion, the promoter CG island hypermethylation, gene mutation, gene deletion and inactivation lead to the abnormal expres-sion of SOCS protein make JAK-STAT continuous activation, resulting in the development and metastasis of tumor. Here, we review the SOCS family members found, composition and molecular structure, the domain of the function, and the latest progress of development in tumor. Based on the important role of SOCS in tumor development, SOCS as a negative regulator factor represent a kind of tumor suppressor genes, has become a new target for tumor therapy.