中文摘要：

目的：探讨乳腺癌化疗后患者合并抑郁情绪与其认知障碍发生的关系。方法采用抑郁自评量表和成套认知神经心理学量表分别对68例乳腺癌术后未合并抑郁状态的患者进行化疗前和化疗后测查，比较化疗前后抑郁评分及认知神经心理学特征的变化。结果与化疗前相比，化疗后患者在抑郁自评量表、简易精神状况检查表、延迟记忆和数字广度倒背成绩方面差异有统计学意义（P 〈0．05）；化疗后合并抑郁患者的简易精神状况检查表、词语流畅性测验量表、即刻记忆、延迟记忆及数字广度倒背得分低于化疗后无抑郁组，差异有统计学意义（P 〈0．05）。结论乳腺癌化疗后合并抑郁患者存在总体认知及记忆功能下降，推测抑郁可能进一步加重乳腺癌术后化疗后认知障碍。

英文摘要：

Objective To investigate the relationships of cognitive impairment and depression in postoperative breast cancer patients who had received chemotherapy. Methods Sixty-eight postoperative breast cancer patients without depression underwent self-rating depression scale and neuropsychological tests before the start of chemother-apy and after six cycles of standard treatment. Results The sixty-three breast cancer patients after chemotherapy performed significantly difference in self-rating depression scale,mini-mental state examination,delayed recall and digit span backward. As compared with non-depression group after chemotherapy,the correct numbers of mini-men-tal state examination, verbal fluency test, immediate recall,delayed recall and digit span backward were lower in the depression group. Conclusion There are total cognition and memory impairment in postoperative breast cancer patients with depression. The evidence suggests that depression maybe further aggravate chemotherapy induced cog-nitive impairment in postoperative breast cancer patients.