中文摘要：

目的 探讨三阴性乳腺癌（TNBC）与非三阴性乳腺癌（NTNBC）患者COMT、APOE基因多态性的差异,从而解释化疗后认知障碍发生。方法 对60例TNBC和60例NTN-BC化疗后的患者进行COMT（rs165599、rs4680、rs737865）,APOE（rs429358、rs7412）5个单核苷酸多态性（SNP）位点的等位基因频率、基因型频率检测。结果 单位点分析结果表明,与NTNBC相比,TNBC在COMT（rs737865）位点上的等位基因分布（P=0.013）,基因型分布（P=0.010）方面差异有统计学意义,而在APOE（rs429358,rs7412）方面两组差异无统计学意义。结论 提示TNBC患者COMT基因的多态性可能是其化疗后认知障碍发生的易感性因子。

英文摘要：

Objective To investigate the differences of the C OMT （catechol-O-methyltransferase） and APOE （apo- lipoprotein E） gene polymorphisms in triple -negative breast cancer （TNBC） and non-triple negative breast cancer （NTNBC） patients, so as to explain the occurrence chemotherapy-induced cognitive impairment in breast cancer patients. Methods 60 TNBC and 60 NTNBC patients after chemotherapy respectively underwent five SNP loci al- lele frequency and genotype frequency detection on COMT （rs165599, rs4680, rs737865）, APOE （rs429358, rs7412）. Results Compared with NTNBC survivors, there was a significant difference in TNBC on the COMT （ rs737865 ） loci allele （P = 0. 013） and genotype （P = 0. 010） , and in respect of APOE （rs429358, rs7412） was no statistically significant differences between the two groups. Conclusion It indicates that the COMT gene poly- morphisms could be a susceptibility factor for cognitive dysfunction in TNBC survivors.