中文摘要：

目的：观察一清胶囊联合胶原蛋白敷贴治疗轻、中度寻常型痤疮脾胃湿热证的临床疗效及对血清白细胞介素-1（interleukin-1,IL-1）、白细胞介素-8（interleukin-8,IL-8）和肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）水平的影响。方法：将120例符合要求的患者随机分为对照组和观察组,对照组56例,观察组57例。两组均给予健康宣教,对照组外用克林霉素磷酸酯凝胶治疗,每日3次,涂患处;晚上睡前外用阿达帕林凝胶治疗。观察组口服一清胶囊,每次2粒,每天3次;外敷胶原蛋白敷料,面部,每晚1次,每次25 min,连续外敷14 d后,2 d 1次。两组患者均治疗6周。观察治疗后比较两组患者临床疗效,治疗前后皮损严重程度评分,治疗前后脾胃湿热证评分,治疗前后IL-1、IL-8和TNF-α水平,治疗前后生存质量评分,并进行安全性评价。结果：观察组有效率为98.25%,对照组有效率为85.45%,差异有统计学意义（χ2=4.672,P〈0.05）;治疗后观察组皮损严重程度评分和脾胃湿热证评分均低于对照组,差异有统计学意义（P〈0.01）;治疗后观察组自我感知、情感功能2个维度评分高于对照组,差异有统计学意义（P〈0.01）;治疗后观察组血清IL-1、IL-8和TNF-α水平均低于对照组,差异有统计学意义（P〈0.01）;观察组不良反应少且轻。结论：一清胶囊联合胶原蛋白敷贴治疗轻、中度寻常痤疮脾胃湿热证能减轻患者皮损症状,提高患者生存质量,减轻炎症反应,提高临床疗效,且安全性好。

英文摘要：

Objective：To observe the clinical curative effect of Yiqing capsule combined with collagen protein application treatment of mild to moderate ache vulgaris with spleen and stomach damp heat syndrome, and its effect on serum interleukin 1 （ IL-1 ）, interleukin 8 （IL-8） and tumor necrosis factor alpha （TNF-α and TNF-α） levels. Methods ：120 cases of patients were randomly divided into the control group and the observation group. Two groups were given health education, the control group was treated with external application clindamycin phosphate gel,3 times a day painted surface of the skln;before going to bed at night topical adapalene gel. The observation group was treated with Yiqing capsule, each 2 capsules,3 times a day;external application of collagen protein dressing ,face, once every ,25 rain each time ,continuous external application after 14 days ,2 days one time. Two groups of patients were treated for 6 weeks. After treatment, compared two groups of patients with clinical curative effect, treatment before and after lesion severity score, before and after the treatment of spleen stomach damp heat syndrome score, before and after treatment with IL-1, IL-8 and TNF-α levels, before and after the treatment, the score of life quality and safety evaluation. Results：The effective rate of observation group was 98.25% ,the control group was 85.45% ,the difference was statistically significant （χ^2 =4. 672, P 〈 0.05 ） ; after treatment,the severity score of the lesion and spleen stomach damp heat syndrome score in the treatment group were lower than the control group, and the difference was statistically significant （ P 〈 0.01 ） ; after treatment, self perception, emotional function of 2 dimensions scores in the observation group were higher than the control group, the difference was statistically significant （P 〈 0.01 ） ;after treatment, the serum IL-1, IL-8 and TNF-α levels in the observation group were lower than those in the control group, the difference was statistically