中文摘要：

目的研究盆架树Winchia calophylla树皮的生物碱成分。方法采用硅胶和Sephadex LH-20柱色谱等方法进行分离和纯化,通过MS、NMR等波谱数据以及X-射线单晶衍射分析进行结构鉴定,采用MTT法测试化合物对7种人体肿瘤细胞（肺癌A549,乳腺癌MCF-7,前列腺癌PC-3,神经胶质瘤U87MG,多发性骨髓瘤U266、MM1.S、MM1.R）增殖的抑制作用。结果从盆架树树皮乙醇提取物的总生物碱部分分离得到1个新单萜吲哚生物碱,命名为盆架树碱B（1）。结论化合物1为新化合物,该化合物对7种人体肿瘤细胞株无增殖抑制作用。

英文摘要：

Objective To investigate the alkaloid constituents from the trunk barks of Winchia calophylla.Methods The constituents were isolated and purified by column chromatography over silica gel and Sephadex LH-20 columns.The structure of the isolated compound was elucidated by MS and NMR spectra,and then confirmed by a single-crystal X-ray crystallographic analysis.The isolated compound was also evaluated for its in vitro cytotoxicity against the proliferation of seven kinds of human cancer cell lines（lung cancer：A549,breast cancer：MCF-7,prostate cancer：PC-3,glioma：U87 MG,multiple myeloma：U266,MM1.S,and MM1.R）.Results A new monoterpenoid indole alkaloid,identified as calophyline B（1）,was isolated from the ethanol extract of the trunk barks of W.calophylla.Conclusion Compound 1 is a new compound,which shows no cytotoxicity against the proliferation of the above human tumor cells.