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雌马酚人体代谢的研究进展
  • 期刊名称:卫生研究
  • 时间:0
  • 页码:787-789
  • 语言:中文
  • 分类:Q946.885[生物学—植物学] Q591[生物学—生物化学]
  • 作者机构:[1]北京大学公共卫生学院,北京100191
  • 相关基金:国家自然科学基金资助项目(No.30872115)
  • 相关项目:GF小鼠模型研究肠道微生态影响大豆异黄酮对LXRα介导的脂代谢信号传导
作者: 王洋|张玉梅|
中文摘要:

雌马酚是大豆异黄酮的代谢终产物,是高度稳定的分子,在体内仅会转变成葡萄糖苷(为主)和硫酸盐的化合物形式,不会发生进一步代谢。摄入雌马酚后,机体能够迅速的吸收,1~2h即可达到峰值浓度,其生物半衰期为7~8h。大部分雌马酚随尿排出,且排出比例不受个体是否为雌马酚产生者影响。雌马酚在体内发挥很强的生物活性,个体间利用雌马酚能力存在差异,且此差异不受是否为雌马酚产生者的影响。

英文摘要:

Equol,the metabolic end product of soybean isoflavones,is a highly stable molecule,only can be changed to β-glucuronide(mainly) /sulfate and not be metabolized further.Equol can be quickly absorbed and reached the peak value in blood after 1-2h.The biological half-life of equol is 7-8h.It was found that majority of equol was discharged through urine and the discharge ratio was not affected by the person who can produce equol or not.Equol plays an important role in health.The ability of using Equol is different among individuals and the differences are not affected by the person who can produce equol or not.

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