中文摘要：

Monoclonal gammopathies 被 monoclonal 的存在描绘在病人与或没有多重骨髓瘤(公里) 的证据的免疫球蛋白， macroglobulinemia，淀粉样变性病(AL ) ，或相关血浆房间 proliferative 混乱。这研究试图评估实验室 monoclonal gammopathies 的诊断人物并且调查在 monoclonal gammopathies 和转变生长因素之间的关联 1 (TGF1 ) 。Immunofixation 电气泳动(IFE ) ，浆液蛋白质电气泳动(SPE ) ，用悬液计测量悬液和尿光链 ELISA 被用于 monoclonal 免疫球蛋白的实验室鉴定。血浆 TGF1 与双抗体 ELISA 被检测。Lightcycler 被用于单个核苷酸多型性(SNP ) 分析。完全， monoclonal 免疫球蛋白(M 蛋白质) 的 2,007 个案例在 10,682 件样品被识别。M 蛋白质的适应于不同地区生活的动物是 IgG 类型 47.1% ， IgA 23.0% ， IgM 8.7% ， IgD 5.3% ，免费的轻链 6.1% ， 9.8% 。在 IFE 的参考，诊断的连贯是浆液光链比率(/)94.4% ， Igs 83% 的 quantitation，轻链 quantitation 80.9% ，并且尿光链比率(/)58.0% 。血浆 TGF1 与正常控制相比显著地被提高。codon 的突变而产生之遗传的频率 10 (C > T ) 也也不没与 M 蛋白质适应于不同地区生活的动物与 M 蛋白质的存在被联系。Monoclonal gammopathies 能与 IFE， SPE， Igs quantitaion 和尿的联合被识别光链决心。尽管 TGF1，在有免疫力的规定的重要 cytokine，在 monoclonal gammopathies 被提高，在编码 TGF1 基因的区域的 SNP 没在这研究授与危险性到 monoclonal gammopathies 的发展。

英文摘要：

Monoclonal gammopathies are characterized by the presence of monoclonal immunoglobulin in patients with or without evidence of multiple myeloma （MM）, macroglobulinemia, amyloidosis （AL）, or a related plasma cell proliferative disorder. This study aims to evaluate laboratory diagnostic characters of monoclonal gammopathies and investigates the correlation between monoclonal gammopathies and transforming growth factor β1 （TGFβ1）. Immunofixation electrophoresis （IFE）, serum protein electrophoresis （SPE）, nephelometry and urine light chain ELISA were used for laboratory identification of monoclonal immunoglobulins. Plasma TGFβ1 was detected with double-antibodies ELISA. Lightcycler was used for single nucleotide polymorphism （SNP） analysis. Totally 2,007 cases of monoclonal immunoglobulin （M protein） were identified in 10,682 samples. The isotypes of M protein were IgG type 47.1%, IgA 23.0%, IgM 8.7%, IgD 5.3%, free light chain κ 6.1%, λ 9.8%. In reference to IFE, the coherency of diagnosis was serum light chain ratio （κ/λ） 94.4%, quantitation of Igs 83%, light chain quantitation 80.9%, and urine light chain ratio （κ/λ） 58.0%. Plasma TGFβ1 was elevated significantly compared to normal control. The allelic frequency of codon 10 （C 〉 T） was neither associated with the existence of the M protein nor with the M protein isotype. Monoclonal gammopathies can be identified with the combination of IFE, SPE, Igs quantitaion and urine light chain determination. Although TGFβ1, an important cytokine in immune regulation, was elevated in monoclonal gammopathies, the SNPs in coding region of TGFβ1 gene did not confer susceptibility to the development of monoclonal gammopathies in this study. Cellular ＆ Molecular Immunology. 2008;5（4）： 293-298.