中文摘要：

目的：观察中药人工周期治疗卵巢早衰的临床效果。方法：将76例患者随机分为2组各38例。对照组给予雌孕激素替代疗法治疗，观察组在对照组的基础上加用中药人工周期治疗。治疗3月后比较2组患者临床疗效。结果：治疗3月及停药3月后，观察组有效率分别为73．68％、60．53％，对照组分别为50．00％、21．06％．2组比较，差异均有显著性意义（P〈0．05）。治疗3月及停药3月，2组患者改艮Kupperman评分均较治疗前降低（P〈0．05），观察组评分降低较对照组更为显著（P〈0．05）。治疗3月及停药3月，2组患者血清卵泡刺激素（FSH）水平升高、雌二醇（E2）（对照组停药3月除外）水平降低，与治疗前比较，差异均有显著性意义（P〈0．05）；停药3月时，观察组laSH、E：值均较对照组改善更明显（P〈0．05）。结论：在雌孕激素替代疗法治疗的基础上，加用中药人工周期治疗卵巢早衰可提高临床疗效。

英文摘要：

Objective. To observe the clinical effect of Chinese medicine menstrual cycle therapy in the treatment of premature ovarian failure. Methods A total of 76 patients were randomly divided into 2 groups, 38 cases in each group. The control group was given hormone replacement therapy, and the observation group was given hormone and Chinese medicine according to the menstrual cycle. Comparison of clinical curative effect was carried out after treatment in the two groups. Results, During the treatment period of 3 months and medication suspension period of 3 months, the total efficiency of the observation group was 73.68%, 60.53% respectively, and was 50.00%, 21.06% respectively in the control group, the difference being significant（P〈 0.05）; the scores of modified Kupperman scale were decreased in both groups（P 〈 0.05 compared with those before treatment）, and the decrease was more obvious in the observation group（P 〈 0.05） serum FSH level was increased and E2 was decreased （not including the medication suspension period of 3 months） in both groups（P 〈 0.05 compared with those before treatment）, and the improvement of FSH and E2 was more obvious in the observation group during the medication suspension period of 3 months （P 〈 0.05）. Conclusion On the basis of Western medicine hormone replacement therapy, the application of Chinese medicine according to the menstrual cycle is more effective for the treatment of premature ovarian failure.