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Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice
  • ISSN号:1672-9145
  • 期刊名称:《生物化学与生物物理学报:英文版》
  • 时间:0
  • 分类:S941[农业科学—水产养殖;农业科学—水产科学] Q516[生物学—生物化学]
  • 作者机构:[1]Department of Endocrinology, Tongii Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China, [2]Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China, [3]Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 相关基金:This work was supported by a grant from the National Natural Science Foundation of China (30971248).
中文摘要:

非酒精的脂肪肝疾病(NAFLD ) 是新陈代谢的症候群的肝的表明并且包括肝的脂肪变性, steatohepatitis,和纤维变性的一个系列。Interleukin-17 (IL-17 ) 被报导了在一些肝疾病的煽动性的前进起一个关键作用。现在的学习被设计在 C57BL/6 老鼠在高胖的导致食谱的 NAFLD 上调查 IL-17 的角色。有 anti-IL-17mAb 的 IL-17 封锁 signicantly 改进了肝功能,稀释了肝的类脂化合物累积,压制了 Kuffer 房间激活,并且减少支持 inflammatory cytokines 铺平激活,它与表明串联的 NF-B 的抑制被联系。我们的数据建议 IL-17 与在 NAFLD 老鼠模型的疾病前进有关,堵住 IL-17 可以是为有 NAFLD 的病人的一条有希望的新奇治疗学的途径。

英文摘要:

Non-alcoholic fatty liver disease (NAFLD) is hepatic manifestation of a metabolic syndrome and includes a spec- trum of hepatic steatosis, steatohepatitis, and fibrosis. Interleukin-17 (IL-17) has been reported to play a critical role in inflammatory progression of some liver diseases. The present study was designed to investigate the role of IL-17 on high fat diet-induced NAFLD in C57BL/6 mice. IL-17 blockade with anti-IL-17mAb significantly improved liver function, attenuated hepatic lipid accumulation, suppressed Kuffer cells activation, and decreased pro- inflammatory cytokines levels, which were associated with inhibition of NF-κB signafing cascades activation. Our data suggested that IL-17 was related to disease progression in NAFLD mouse model and blocking IL-17 may be a promis- ing novel therapeutic approach for patients with NAFLD.

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期刊信息
  • 《生物化学与生物物理学报:英文版》
  • 北大核心期刊(2004版)
  • 主管单位:
  • 主办单位:中国科学院上海生物化学研究所
  • 主编:
  • 地址:上海岳阳路319号
  • 邮编:200031
  • 邮箱:abbs@sibs.ac.cn
  • 电话:021-54920956 54920955
  • 国际标准刊号:ISSN:1672-9145
  • 国内统一刊号:ISSN:31-1940/Q
  • 邮发代号:4-210
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引(扩展库),美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:5851