中文摘要：

目的建立载瘤动脉类似于人体颈内动脉虹吸段形态的犬动脉瘤模型。方法用3．0TMR行3维（3D）-时间飞跃（TOF）-MR血管成像（MRA）序列采集人头颅横断面医学数字图像通讯（DICOM）格式图像，导入MaterialiseMimics和Pro—E软件重组，做出带孔管状3D数字模型。根据该文件利用快速原型技术制作出TangoPlus材料的实体模型并硅胶涂层。分别将6只实验犬左侧颈总动脉远端和右侧颈总动脉近端结扎离断。将游离的左侧颈总动脉通过黑线牵引从下而上，游离的右侧颈总动脉从右到左穿过模型，并从模型上的孔牵出。处理游离的双侧颈总动脉外膜后，行端侧吻合，得到形态类似于人颈内动脉虹吸段动脉瘤形态的动脉瘤模型。动物模型完成后即刻及l周MRA随访，1周行血管造影并置入测试支架测试。结果6只犬均成功建立了形态类似于人颈内动脉虹吸段动脉瘤的动脉瘤模型。MRA显示6只犬的载瘤动脉通畅，显影良好。置入支架后1只犬死亡；5只术后1个月随访，模型内血管均通畅，其中3只弯曲处血管变扁，2只无明显管腔形态改变。结论制作的模型弯曲血管与人体颈内动脉虹吸段形态高度相似，可作为颅内神经介入材料及其输送系统的研究测试以及神经介入医师培训的工具。

英文摘要：

Objective The aim of the experiment is to make an intracranial aneurysm model in canine. Methods A digital tube was made based on raw magnetic resonance images of the human intracranial carotid artery. Then 6 tubes were made in the 3D rapid prototyping machine and coated with silicone. Finally we isolated the common carotid arteries of 6 canines and made them go through the tubes and anastomosed them end-to-side to get the aneurysm model Six stents were implanted after one week. Results Six aneurysm models were successfully made in canines. The parent artery had similar geometry of the human carotid siphon. All the aneurysms and parent arteries were patent in one week＇s follow-up. One canine died of excessive anesthesia after stenting. Two vascular models kept patent in one month without stenosis. The other 3 had some stenosis on the bends of the vessel. Conclusions The aneurysm model in the experiment has high flexibility and reliability. The model provides an effective tool for research and testing neurovascular devices. It＇s also a useful device to train the neuroradiologists and interventional physicians.