目的观察采用颅内专用覆膜支架及其输送系统通过颅段颈内动脉(CICA)骨性管道和生理弯曲,治疗颅段颈内动脉病变的效果。方法采用颅内专用覆膜支架,以血管内技术治疗13例CICA病变。其中巨大假性动脉瘤4例、巨大动脉瘤4例、宽颈小动脉瘤3例、巨大假性动脉瘤伴颈动脉海绵窦瘘(CCF)1例、CCF1例。颅内专用覆膜支架释放前均行患侧颈内动脉球囊闭塞试验(BOT)和DSA。术后3~16个月施行DSA随访和临床随访。结果13例患者BOT均耐受良好,DSA证实前、后交通动脉开放良好。13例覆膜支架及其输送系统均顺利通过CICA到达病变靶区。病变及覆膜支架释放部位分别为:C3~4段4例、C4~5段4例、C6~7段5例。覆膜支架释放后即刻DSA示7例动脉瘤不再显影,4例显示少量内漏,1例CCF覆膜支架释放后流量明显减少,1例假性动脉瘤伴CCF覆膜支架释放后动脉瘤消失,但残存低流量CCF。13例中1例动脉瘤破裂性蛛网膜下腔出血患者术后9d因血管广泛痉挛而死亡。12例随访DSA均显示覆膜支架放置处血管通畅,其中2例显示轻度狭窄;6例术后存在内漏,其中4例DSA随访7~16个月后内漏消失,1例再次置入覆膜支架治疗后内漏消失;1例CCF,3个月后随访仍显示低流量瘘。存活患者临床随访3~16个月未发生支架覆盖段相关分支堵塞后的并发症。结论颅内覆膜支架及其输送系统的柔顺性足以使其通过迂曲的CICA,到达颅内病变血管处,有效治疗CICA病变。颅内覆膜支架的远期疗效有待长期随访,其贴壁性能仍需进一步完善。
Objective To investigate the flexibility of both the covered stents specially designed for use in intracranial vasculature and the delivering system in passing through the bone tube and the physiological curves of the cranial internal carotid artery (CICA) to reach the targeted area, the performance (adherence) of the covered stents in occluding vascular wall diseases and the impact on the vascular branches of the covered segment. Methods The covered stents specially designed for use in intracranial vasculature were used to treat 13 patients with CICA diseases using endovascular techniques. There were 4 huge pseudoaneurysms, 4 giant aneurysms, 3 small wide-necked aneurysms, 1 giant pseudoaneurysm with concurrent internal carotid cavernous fistula ( CCF), and 1 CCF. Prior to the detachment of the covered stents, balloon occlusion test (BOT) of the internal carotid artery on the diseased side and whole-brain digital subtraction angiography (DSA) were performed in all the patients. Three to 16 months following procedure, DSA and clinical follow-ups were performed. Results Thirteen patients all tolerated the BOT well with the DSA demonstrating well-opened anterior and posterior communicating arteries. The covered stents and the delivering systems all successfully passed CICA to reach the targeted diseased area, with the diseased segments of the internal carotid artery including C3-CA in 4 cases, CA-C5 in 4 and C6-C7 in 5. Immediately following the detachment of the covered stents, DSA demonstrated that 7 aneurysms were completely occluded, 4 aneurysms had slight endoleak, and 1 CCF had markedly-decreased blood flow through the fistula. In the patient with concurrent pseudoaneurysm and CCF, the pseudoaneurysm disappeared and the blood flow through the fistula was markedly-reduced immediately following the stenting procedure. Apart from one patient with aneurysmal subarachnoid hemorrhage who died due to extensive vascular spasm on the 9th day following the stenting procedure, all the other 12 patien