中文摘要：

从早胚胎导出的胚胎的干细胞(转换字符) 拥有二个重要特征：自强和 pluripotency，它使转换字符理想的种子房间成为那能潜在地为临床上治好很多退化、基因的疾病被利用。然而，在房间移植以后的道德的担心和有免疫力的拒绝限制了转换字符的临床的申请。幸好，在导致的 pluripotent 干细胞(iPSC ) 的最近的进展研究清楚地证明了从各种各样的种类的区分的体的细胞能是进由宫外地表示几个抄写因素的联合的 pluripotent 状态的 reprogrammed，它高度在转换字符被充实。这开创性的成就能围绕大多数转换字符面对了的限制。然而，如果 iPS 房间排队，它仍然保持挑战性，特别人的 iPSCs 线，可得到充分 pluripotent。因此，建立一个分子的标准把更好优秀的 iPSCs 与劣等的区分开来是前提。

英文摘要：

Embryonic stem cells （ESCs） derived from the early embryos possess two important characteristics：self-renewal and pluripotency,which make ESCs ideal seed cells that could be potentially utilized for curing a number of degenerative and genetic diseases clinically.However,ethical concerns and immune rejection after cell transplantation limited the clinical application of ESCs.Fortunately,the recent advances in induced pluripotent stem cell （iPSC） research have clearly shown that differentiated somatic cells from various species could be reprogrammed into pluripotent state by ectopically expressing a combination of several transcription factors,which are highly enriched in ESCs.This ground-breaking achievement could circumvent most of the limitations that ESCs faced.However,it remains challenging if the iPS cell lines,especially the human iPSCs lines,available are fully pluripotent.Therefore,it is prerequisite to establish a molecular standard to distinguish the better quality iPSCs from the inferior ones.