本文的目的是利用介质阻挡放电制备聚丙烯酸生物功能薄膜。利用接触角测量仪,傅立叶变换红外光谱(FT-IT),原子力显微镜(AFM),X射线光电子能谱(XPS)对功能薄膜进行表征。通过体外细胞培养和富血血小板黏附实验,讨论了含有羧基功能团薄膜的结构、成分以及性能对其生物相容性的影响。实验表明:等离子放电参数对合成羧基功能薄膜的结构和成分有较大影响,且聚合的羧基功能薄膜能较好地促进细胞在其表面的黏附以及生长。
The study was aimed at producing plasma polymerized acrylic acid (PPAA) functional coating for biomedical applications. Dielectric barrier discharge (DBD) was used to deposit functional films from acrylic acid vapors. The films were characterized by water contact angle, Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). By in vitro cell culture and rich blood platelet adhesion tests, effects of the film structure and chemical components on biocompatibilities of the films were studied. The results show that plasma parameters of pulse frequency, plasma power, discharge mode, gas pressure, and duty cycle, have great influence on PPAA coatings, and efficient cell adhesion of the PPAA coatings surface was demonstrated. Biological effects of the functional coatings were discussed in detail.