中文摘要：

维生素D及其代谢物在癌症中的作用日益受到重视，然而在肺癌中的探索尚浅。维生素D在肺癌中的抗增殖作用涉及3个重要环节，即维生素D受体、27羟化酶、24羟化酶。此外，维生素D还间接地影响胰岛素样生长因子、转化生长因子β及Wnt／β-catenin的信号传导而发挥抗癌作用。维生素D受体、27羟化酶及24羟化酶在正常肺组织及肺癌中的差异性表达，为揭示维生素D对肺癌的抑癌机制提供了线索并奠定了研究基础。

英文摘要：

In recent years a large number of studies have been conducted to investigate the role ol vita- min D and its metabolites in cancer. However, the picture for lung cancer is not clear at the present time. There are three integral components of the vitamin D pathway： the vitamin D receptor （VDR）, CYP27B1 and CYP24A1. Besides, vitamin D inhibits the carcinogenesis of lung by indirectly influencing IGF signaling, TGF-βsignaling, and Wnt/β-catenin signaling pathway. Their differential expressions in normal lung tissue and lung cancer offer clues and lay the foundation for research of the inhibitory function in lung cancer patho- genesis