中文摘要：

Esophageal squamous cell carcinoma continues toheavily burden clinicians worldwide. Researchers havediscovered the genomic landscape of esophagealsquamous cell carcinoma, which holds promise for anera of personalized oncology care. One of the mostpressing problems facing this issue is to improve theunderstanding of the newly available genomic data,and identify the driver-gene mutations, pathways, andnetworks. The emergence of a legion of novel targetedagents has generated much hope and hype regardingmore potent treatment regimens, but the accuracy ofdrug selection is still arguable. Other problems, suchas cancer heterogeneity, drug resistance, exceptionalresponders, and side effects, have to be surmounted.Evolving topics in personalized oncology, such asinterpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, andfuture perspectives, will be discussed in this editorial.