中文摘要：

研究了双三氟甲烷磺酰亚胺阴离子Tf2N--分别与5种不同阳离子组成的离子液体对产紫青霉菌（Penicillium purpurogenum Li-3）的生长、代谢、细胞膜透性及全细胞催化活性的影响.结果表明,[N1,4,4,4]Tf2N对产紫青霉菌的生长有促进作用,[Py14]Tf2N,[Bmim]Tf2N,[BPy]Tf2N和[P6,4,4,4]Tf2N 4种离子液体对产紫青霉菌的生长则均有不同程度的抑制.代谢活力保留值R的测定结果表明,[P6,4,4,4]Tf2N和[N1,4,4,4]Tf2N对产紫青霉菌体细胞表现出相对较高的生物相容性;5种离子液体对菌体细胞的细胞膜透性均有改善作用.全细胞催化反应数据显示,最优离子液体为[Py14]Tf2N,当其加入量为25%,反应84 h后,单葡萄糖醛酸基甘草次酸（GAMG）产率高达95.38%.5种离子液体对产紫青霉菌的生长、代谢、细胞膜透性及全细胞催化活性的影响不仅与阴离子Tf2N^-有关,阳离子的组成、结构和性质也发挥重要的作用.

英文摘要：

Penicillium purpurogenum Li-3 cells properties of growth, metabolism, permeability of cell membrane and catalysis were studied in five ionic liquids composed with anion Tf2N^- and five different cations. The results showed that,the ionic liquids [Py14]Tf2N,[Bmim]Tf2N,[BPy]Tf2N and [P6,4,4,4]Tf2N had inhibitory effect on the growth of penicillium purpurogenum Li-3 while ionic liquid [N1,4,4,4]Tf2N had a promoting effect. Through metabolic activity determination of retention value（ R） in ionic liquids,[P6,4,4,4]Tf2N and [N1,4,4,4]Tf2N showed relatively high biocompatibility to cells. At the same time,five ionic liquids on cell membrane permeability were improved effect. Whole-cell catalysis results displayed that[Py14]Tf2N was optimal ionic liquid. When the addition of [Py14]Tf2N was 25%,after 84 h,glycyrrhetinic acid monoglucuronide（ GAMG） rate and glycyrrhizin acid（ GL） conversion rate were as high as 95. 38% and99. 84%. Therefore,the addition of [Py14]Tf2N,greatly promoted the formation of conversion and product. It showed that the effects of five kinds of ionic liquids on cells properties of growth and metabolism,cell membrane permeability and the whole cell catalytic activity were not only related to the anion Tf2N^-,but also played an important role in the composition,structure and properties of the cations.