中文摘要：

以微囊化产紫青霉细胞（Penicillium purpurogenum Li-3）催化甘草酸（GL）定向合成具有更高生物利用度、甜度以及安全性的单葡萄糖醛酸基甘草次酸（GAMG）为目的,研究固芯液化技术对微囊化细胞使用性能的影响。结果显示,液芯微囊化细胞的生长情况和传质性能明显优于固芯微囊化细胞,并在第1批次催化反应中,液芯微囊化细胞的相对活性达到98.7%,比固芯微囊化细胞（72.7%）要高。9批次重复利用实验表明,与固芯微囊化细胞相比,液芯微囊化细胞的相对活性较高,而机械强度和操作稳定性要稍显逊色。此外,固芯液化的技术与条件对微囊化细胞发挥最佳催化效果至关重要。

英文摘要：

The effect of solid core liquefaction of microencapsulated penicillium purpurogenum Li-3 cells on its performance of improving hydrolysis of glycyrrhizin （GL） into glycyrrhetinic acid monoglucuronide （GAMG） to have better bioavailability, sweetness, and security was investigated in this paper. The results showed that the mass transfer performance and growth of alginate-chitosan liquid core microencapsulated cells was obviously better than solid core microencapsulated cells. The first batch of catalytic reaction, compared with solid core microencapsulated cells （72.7%）, the relative catalytic activity （98.7%） of liquid core microencapsulated cells was higher. But the mechanical strength and repeated useage of liquid core microencapsulated cells weren＇ t as good. In addition, the key techniques and technological conditions used for solid core liquefaction of microencapsulated cells was crucial on the catalytic effect.