中文摘要：

慢性疼痛是一个巨大的医疗难题，目前传统的治疗方法都存在一定局限性，单纯疱疹病毒Ⅰ型载体具有天然嗜神经性，适合神经系统转基因治疗。现就单纯疱疹病毒Ⅰ型载体及其转前脑啡肽原基因在炎性疼痛、神经病理性疼痛、癌性疼痛中的应用作一综述。

英文摘要：

Treatment of chronic pain is extremely difficult. Current traditional treatments may be limited with regard to analgesic efficacy or side effects. Neurotropic herpes simplex virus type Ⅰ （ HSV- Ⅰ ） based vector is suit for gene transfer applications in the nervous system. The developments of HSV-Ⅰ-based vectors expressing proenkephalin in rodent models of imflammatory pain, neuropathic pain and pain resulting from cancer in bone were reviewed.