中文摘要：

目的观察Microspinal导管在大鼠蛛网膜下腔长期置管中的应用。方法40只250～300g纯种清洁级雄性SD大鼠，随机分为Microspinal导管组（M组，n=20）和PE-10导管组（P组，n=20），术后没有瘫痪的大鼠进行运动协调能力恢复评分测试，置管3d后行利多卡因试验证实导管是否在蛛网膜下腔，证实在蛛网膜下腔的大鼠蛛网膜下腔注射吗啡，用热痛刺激仪测缩腿反应潜伏期（PWL），大鼠进行解剖处死前10min蛛网膜下腔注射5止亚甲兰对导管位置定位。结果同P组比较，M组大鼠术后死亡率差异无统计学意义（P〉0．10），术后致残率差异有显著性（P〈0．05），利多卡因试验及亚甲兰定位导管位置两组比较差异无统计学意义（P〉0．10），M组术后运动协调能力恢复快，两组评分比较有显著性差异（P〈0．05），两组大鼠蛛网膜下腔注入吗啡后热痛阈值（PWL）比较差异无显著性（P〉0．05）。结论Microspinal导管组致残率明显低于PE-10组，术后运动协调功能恢复快，是一种适合于大鼠蛛网膜下腔置管的实验材料。

英文摘要：

Objective To compare the smaller Microspinal catheter with standard PE10 catheter for intrathecal（IT） catheterization in rats. Methods 40 Sprague-Dawley rats,weighting 250 - 300 g were randomLy divided into Microspinal group （M group, n = 20） and PE10 group（P group, n = 20）. The Microspinal or PE10 catheter was implanted in the lumbar subarachnoid space through the atlantoccipital membrane in rats. Surviving rats without paralysis were tested for motor function on postoperative 3 latency（PWL）. Methylene blue was injected IT immediately before the spinal days. 2 % lidocaine of 20 μL IT was given, Different doses of IT morphine were injected to demonstrate the functionality of the catheters by measuring paw withdrawl necropsy in each rat to identify the catheter tip location. Result There were no significant difference between M group and P group in immediate death and lidocaine test and methylen blue location（P 〉 0.05）. There were markedly diffent from overt paralysis between two groups. Overt paralysis after operation and motor function scores were markedly different from control group （P 〈 0.05）.Rats in both group showed a dose-depended response to IT morphine. Conclusion Therefore, the Microspinal catheter is very suit for IT catheterization in rats because it causes less paralysis and provides better recovery of mortor function.