中文摘要：

背景青紫的病人由于血氧不足和另外的 reasons.Ghrelin 有潜在的生长延迟和营养不良是在生长和这研究的心血管的 activities.The 目的上有效果的新奇内长的生长荷尔蒙促泌素是用一头不成熟的小猪评估血浆水平和 ghrelin 和像胰岛素的生长 factor-1 ( IGF-1 )的心肌的表示与减少的肺的血流动长期的青紫的先天的心缺点当模特儿。12 头刚断奶的中国小猪作为控制与肺的动脉 banding 或假冒的操作经历了主要肺的动脉左中庭分流的过程的方法。四个星期以后，血液动力学的参数是为血浆 ghrelin 的连接 measured.Enzyme 的 immunosorbent 试金， IGF-1 水平测量被执行。室的 ghrelin 和 IGF-1 mRNA 表情被量的即时聚合酶链反应测量。四个星期在外科的过程以后结果，青紫的模型生产了更低的动脉的氧紧张((68.73 吗？？

英文摘要：

Background Cyanotic patients have potential growth retardation and malnutrition due to hypoxemia and other reasons. Ghrelin is a novel endogenous growth hormone secretagogue that has effects on growth and cardiovascular activities. The aim of this study was to evaluate the plasma level and myocardial expression of ghrelin and insulin-like growth factor-1 （IGF-1） using an immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow. Methods Twelve weanling Chinese piglets underwent procedures of main pulmonary artery-left atrium shunt with pulmonary artery banding or sham operation as control. Four weeks later, hemodynamic parameters were measured. Enzyme-linked immunosorbent assay for plasma ghrelin and IGF-1 level measurement were performed. Ventricular ghrelin and IGF-1 mRNA expressions were measured by quantitative real-time polymerase chain reaction. Results Four weeks after surgical procedure, the cyanotic model produced lower arterial oxygen tension （（68.73±15.09） mmHg）, arterial oxygen saturation （（82.35±8.63）%）, and higher arterial carbon dioxide tension （（51.83±6.12） mmHg）, hematocrit （（42.67±3.83）%） and hemoglobin concentration （（138.17±16.73） g/L） than the control piglets （（194.08±98.79） mmHg, （96.43±7.91）%, （36.9±4.73） mmHg, （31.17±3.71）%, （109.83±13.75） g/L） （all P 〈0.05）. Plasma ghrelin level was significantly higher in the cyanotic model group in comparison to the control （P=0.004）, and the plasma IGF-1 level was significantly lower than control （P=0.030）. Compared with control animals, the expression of ghrelin mRNAs in the ventricular myocardium was significantly decreased in the cyanotic model group （P=0.000）, and the expression of IGF-1 mRNAs was elevated （P=0.001）. Conclusions Chronic cyanotic congenital heart defects model was successfully established. Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasm