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Association of TBX5 gene polymorphism with ventricular septal defect in the Chinese Han population
  • ISSN号:0366-6999
  • 期刊名称:Chinese Medical Journal
  • 时间:0
  • 页码:30-34
  • 语言:英文
  • 分类:R714.246[医药卫生—妇产科学;医药卫生—临床医学]
  • 作者机构:[1]首都医科大学附属北京妇产医院,北京100026
  • 相关基金:国家自然科学基金项目(30672193)
  • 相关项目:宿主易感基因多态性与小儿先天性心脏病易感性研究
中文摘要:

目的:探讨硫酸镁联合硝苯地平治疗中重度妊娠期高血压综合征的临床疗效。方法:选取2013年5月-2014年10月我院收治的中重度妊娠期高血压综合征患者70例,随机将患者分为研究组和对照组,每组35例。对照组患者应用硫酸镁治疗,研究组患者给予硫酸镁联合硝苯地平治疗,比较两组患者的临床疗效、血压变化、血液粘度、24 h尿蛋白含量以及血细胞压积情况。结果:研究组治疗总有效率显著优于对照组,差异具有统计学意义(P〈0.05);两组患者治疗后的血压水平显著低于治疗前,且研究组显著优于对照组,差异具有统计学意义(P〈0.05);两组患者治疗后的血液粘度、24 h尿蛋白含量及血细胞压积显著优于治疗前,且研究组优于对照组,差异具有统计学意义(P〈0.05)。结论:硫酸镁联合硝苯地平治疗中重度妊娠期高血压具有较好的临床疗效,能够显著改善患者的临床症状。

英文摘要:

Objective: To study the clinical efficacy of magnesium combined with nifedipine on the treatment of pregnancy-induced hypertension with different stages. Methods: 70 cases with moderate to severe pregnancy-induced hypertension who were treated in our hospital from January 2012 to November 2014 were selected and divided into the study group and the control group,with 35 cases in each group. The patients in the control group were received the magnesium sulfate, while the patients in the study group were given the magnesium combined with nifedipine. Then the clinical efficacy, the blood pressure, the blood viscosity, 24 h urine protein and the hematocrit of two groups were observed and compared. Results: The total efficiency rate of the study group was higher than that of the control group, and the difference was statistically significant(P〈0.05); After the treatment, the blood pressure of the two groups were lower than before, and the study group was lower than that of the control group with statistically significant differences(P〈0.05); After the treatment, the blood viscosity, 24 h urine protein and the hematocrit of the two groups were significantly better than before, and the study group was lower than that of the control group with statistically significant differences(P〈0.05). Conclusion:Magnesium combined with nifedipine in treatment of moderate to severe pregnancy-induced hypertension had better clinical efficacy, can significantly improve the clinical symptoms.

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期刊信息
  • 《中华医学杂志:英文版》
  • 中国科技核心期刊
  • 主管单位:中国科协
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京东四西大街四十二号
  • 邮编:100710
  • 邮箱:cmj@cma.org.cn
  • 电话:010-85158321
  • 国际标准刊号:ISSN:0366-6999
  • 国内统一刊号:ISSN:11-2154/R
  • 邮发代号:2-920
  • 获奖情况:
  • 1997、1998、1999年获中国科协优秀科技期刊择优资...,1992、1997年连续两年荣获全国优秀科技期刊和中国...,中国期刊方阵双高期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国科学引文索引(扩展库),美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊
  • 被引量:3319