中文摘要：

鼻咽癌是发生于鼻咽腔内的恶性肿瘤,与EB病毒感染关系密切,由于发生在鼻咽部位置较隐蔽,早期症状不典型,常容易误诊和漏诊,而且鼻咽癌易发生早期转移,发现时多已是晚期,提高早期诊断的敏感性和治疗的有效性有着重要意义。上皮-间质转化（EMT）是胚胎发育的重要过程,但是在肿瘤发生过程中也会发生EMT,使肿瘤细胞发生变形,获得迁移和运动的能力,在肿瘤发生浸润和转移过程中起关键作用。该文主要介绍EMT过程中标志性蛋白的变化以及转录因子、生长因子、炎症等在EMT中的作用机制,进一步综述EMT在EB病毒感染所致鼻咽癌发生浸润和转移中的重要作用。

英文摘要：

Nasopharyngeal carcinoma （NPC） is a malignant neoplasm originating from nasopharyngealregion and highly related to EB virus. NPC usually happens in a concealed region with atypical clinical symp-toms and may easily metastasize in the early stage, which makes it very important to enhance the sensitivity ofearly diagnosis and effectiveness of treatment. Epithelial-mesenchymal transition （ EMT ） is an importantprocess in the embryonic development. EMT plays an important role in the invasion and metastasis of tumorcells by changing cancer cellular morphology. Hero is mainly to introduce the biomarkers changes and the roleof transcription factors, growth factors, and inflammation in EMT during the whole process, in order to summa-rize the role of EMT in EBV-related NPC invasion and metastasis.