中文摘要：

目的：评价血清中可溶性趋化因子配体16（CXCL16）水平在克罗恩病（CD）与溃疡性结肠炎（UC）中的诊断价值以及与其他炎性标志物、临床疾病活动度、内镜下疾病活动度的关系。方法：收集了2011年武汉大学中南医院消化内科确诊为炎症性肠病（IBD）病例55例,其中UC 29例,CD 24例,纳入年龄和性别匹配的55例正常人作为对照。内镜下对疾病程度进行评分,运用ELISA方法检测血清中CXCL16水平。结果：UC和CD患者血清中CXCL16水平分别为（1.99±0.47）ng/ml和（2.24±0.74）ng/ml,均较正常对照[（1.54±0.34）ng/ml]明显升高（P〈0.05）;血清CXCL16水平与CDAI评分（r=0.588,P〈0.05）和CRP（r=0.427,P〈0.05）均显著相关,CXCL16对炎症性肠病具有一定诊断学价值[CD曲线下面积为0.841（95%CI,0.741-0.941）;UC曲线下面积为0.792（95%CI,0.698-0.887）,P〈0.01],但是特异性较低,尤其在UC中更明显。结论：CXCL16可作为IBD血清学分子标志物并用于对IBD诊断的辅助工作。

英文摘要：

Objective：To assess the level of soluble chemokine ligand 16（CXCL16）in Crohn＇s disease（CD）and ulcerative colitis（UC）,and to study its diagnostic value,and its correlation with other inflammatory markers,clinical disease activity and endoscopic disease activity.Methods：Fiftythree confirmed cases of inflammatory bowel disease（IBD）（29UC and 24CD）and 55 age and sex matched healthy controls were recruited for the study.CXCL16 level in the sera were quantitatively measured by using a commercial enzyme-linked immunosorbent assay.Endoscopic evaluation of the intestine was done in most of the IBD patients.Statistical evaluation of data was done,using the SPSS17 software.T-tests,receiver operating characteristic（ROC）curve analysis,and Pearson＇s correlation test were done.Results：CXCL16level in UC（[1.99±0.47]ng/ml）,and in CD（[2.24±0.74]ng/ml）were both significantly higher（P〈0.05）than in control group（[1.54±0.34]ng/ml）.Only in CD,CXCL16 was significantly correlated to CDAI（r=0.588,P〈0.05）,and CRP（r=0.427,P〈0.05）.No significant correlation between CXCL16 and endoscopic scores（SES-CD,Rachmilewitz score in UC）were identified in either CD or UC.CXCL16 was found to have diagnostic value（AUC：0.841[0.741-0.941]in CD versus 0.792[0.698-0.887]in UC,P〈0.001）.However,the specificity was low,especially in UC.Conclusion：CXCL16is a serological biomarker of IBD,which can be used as an adjunct diagnostic tool for the diagnosis of IBD.