中文摘要：

目的：观察龙牙楤木总皂苷对缺血再灌注损伤心肌粘附分子sVCAM-1表达及MDA、GSH—PX的影响。方法：可逆性冠脉左前降支结扎缺血45min再灌注6h复制MI／R模型，Wistar雄性大鼠30只，随机分成模型组、龙牙楤木组、波立维组，每组10只。HE染色观察心肌病理学变化，检测血清LDH含量，测定心肌MDA、GSH—PX活性，ELISA法测定血清sVCAM-1的表达。结果：与模型组比较，龙牙楤木总皂苷、波立维均能显著降低缺血再灌注大鼠血清LDH含量，显著升高GSH．Px的活性，升高MDA含量，缺血45min再灌注6h血清sVCAM-1有明显表达，各组之间无统计学差异。结论：龙牙梅木总皂苷对MIRI有保护作用，可能是通过减少MDA含量、升高GSH-PX活力，对抗氧自由基对心肌细胞的毒害作用，减轻心肌细胞的损伤而实现的。

英文摘要：

Objective： To investigate the effects of Aralosides on expression of inflammatory molecule sVCAM-1 and the activity of Malcic Dialdchyde （MDA） ＆ Glutathione Peroxidase （GSH-PX） in rats after myocardial ischemia/reperfusion （MICR） injury. Methods： A model of myocardial ischemia 45min followed by 6h reperfusion was made by reversibly ligating coronary left descending artery. 30 Wistar rats were divided randomly into 3 groups ： Ichemia reperfusion Group, Aralosides Goup, Plavix Group. HE staining was used to observe the pathological changes of myocardial issues. The activity of MDA and GSH-PX was measured , too. ELISA was used to determine sVCAM-1 expression in myocardium. Results： In rats treated by Aralosides or Plavix, the lactate dehydrogenase LDH） activity was significantly decreased. Meamwhile , Aralosides and Plavix raised the activity of Malcic Dialdchyde （MDA） ＆ Glutathione Peroxidase （GSH- PX） . sVCAM-I expression was detected in myocardium after ischemia 45min followed by 6h reperfusion. In rats treated by Aralosides or Plavix, sVCAM-1 expression remained unchanged. Conclusion： Aralosides could protect myocardium from inflammatory injury during MI/R. It had the actions of decreasing MPO activity.