中文摘要：

外泌体是由不同类型细胞释放的膜性囊泡，直径约30～100nm，能够通过mRNAs、miRNAs和蛋白质等的传递介导细胞间相互作用。外泌体作为肿瘤学研究的热点，其在肿瘤发生、发展、临床诊断和治疗方面具有重要的研究价值。本文对外泌体与乳腺癌微环境、耐药的关系及其在乳腺癌诊断和治疗中的研究进展进行综述，以期为寻找乳腺癌诊断与治疗新靶点提供思路。

英文摘要：

Exosomes are small （30 - 100 nm） membrane vesicles secreted by various cell types, they mediate cell-to-cell communication by transferring mRNAs, miRNAs, and proteins. As a hotspot in the research of oncology, exosomes have potential values in the research of development, diagnosis and treatment of cancer. This paper briefly reviews the relationship between breast cancer microenvironment, drug resistance and exosomes and its progress in breast cancer diagnosis and treatment, in order to propose new diagnostic and therapeutic strategies.