中文摘要：

试图观察空多孔的钛 prostheses (HPTP ) 的 osseointegration 的这研究在组织学的使用的兔子和 biomechanical 观点与 cancellous 骨头矩阵(CBM ) 装载了。试验性的样品被植入进 66 只新西兰兔子的侧面的大腿骨的髁，分配了进下列组：非多孔的修复术组(组 A， n=22 ) ；HPTP 组(组 B， n=22 ) ；HPTP+CBM 组(组 C， n=22 ) 。兔子手术后地在 3， 8 和 12 个星期被牺牲。X 光检查分析，显微镜学技术和词法测量软件和机械测试被用于评估。在每次指，包围 implants 的纸巾在所有这些组是类似的，与进 2 公里回合的多骨的向内长，洞在组 B 和 C 为缺点观察了。然而，内部骨头形成比在组在不同时间的 B 指的在组 C 显著地更好(P < 0.01 ) 。Biomechanically，撤退力量比在组 A 在组 B 和 C 是显著地更大的(P < 0.01 ) ，没有组 B 和 C 之间的差别(P > 0.05 ) 。这些结果建议那根骨头能长成 HPTP 的洞完成更多的稳定的锁住固定，和那些 osteogenic 材料，例如 CBM，能提高成骨完成在 implant 和主人骨头之间的更好的 osseointegration。

英文摘要：

This study aimed to observe the osseointegration of hollow porous titanium prostheses （HPTP） loaded with cancellous bone matrix （CBM） in rabbits using histological and biomechanical perspectives.Experimental samples were implanted into the lateral femoral condyles of 66 New Zealand rabbits,allocated into the following groups：non-porous prosthesis group （Group A,n=22）;HPTP group （Group B,n=22）;HPTP＋CBM group （Group C,n=22）.The rabbits were sacrificed at 3,8 and 12 weeks,postoperatively.X-ray analyses,microscopy techniques and morphological measurement software and mechanical tests were used for evaluation.At each time point,the tissues surrounding the implants were similar in all of the groups,with bony in-growth into the 2-mm round holes observed for the defects in Groups B and C.However,the internal bone formation was significantly better in Group C than in Group B at different time points （P〈0.01）.Biomechanically,the pull-out forces were significantly greater in Groups B and C than in Group A （P〈0.01）,with no difference between Groups B and C （P〉0.05）.These results suggest that bone can grow into the cavities of HPTP to achieve more stable locking fixation,and those osteogenic materials,such as CBM,can enhance osteogenesis to achieve better osseointegration between the implant and the host bone.