中文摘要：

聚合物胶束由于具有优良的组织渗透性、增容效果好、结构多样性和热稳定性等特点,成为国内外研究的热点之一。本文综述了近几年发展起来的一些具有特殊结构和特殊性能的双亲性嵌段聚合物胶束的研究进展,详细阐述了RAFT聚合法合成聚合物胶束的机理和优势,表明了RAFT聚合法可直接在水溶液中方便快捷地制备出温度和pH双响应性聚合物胶束。然而,当聚合物胶束的浓度低于其临界胶束浓度时,胶束的稀释效应大大影响了其实际应用,为提高聚合物胶束的稳定性,文章归纳总结了一系列有关壳交联聚合物胶束的制备方法及研究进展。最后,文章展望了聚合物胶束在药物可控释放、靶向、生物成像、催化剂负载及其他领域的应用前景。

英文摘要：

The rapid progress of polymeric micelles,which due to their attractive advantages such as excellent tissue permeability,compatibilization effect,structural diversity and thermal stability,has raised interest in recent years.In this review,the research progress of amphiphilic block copolymer micelles with special structure and special properties is discussed.The formation mechanism and advantage of polymeric micelles via RAFT polymerization method are introduced.Different thermo-and pH-responsive micelles can be prepared quickly and easily in aqueous solution via RAFT polymerization method.However,dilution effect of polymer micelles greatly affect its practical application when the concentration of the polymer micelle below its critical micelle concentration.To improve the stability of polymer micelles,several methods to prepare polymeric cross-linked micelles are summarized.Finally,the current challenges for the polymeric micelles potential applications in controlled drug release,targeting,biological imaging,catalyst immobilization and other areas are highlighted.