中文摘要：

LRRC4，充满白氨酸的重复 C4 蛋白质，在人被识别了(GenBankaccession 没有。AF196976 ) ，老鼠(GenBank 同意没有。DQ177325 ) ，老鼠(GenBank 就职 No.DQ119102 ) 并且牛(GenBank 同意没有。DQ164537 ) 与相同领域。以他们的类似，把 LRRC4 编码为这的基因四哺乳动物的种是剩菜公猪因此对应于一样的基因实体。基于以前的研究，并且在 situ 杂交使用，我们发现那 LRRC4 有最强壮的表示在海马趾的 CA1 和 CA2，有牙齿的回转区域的小粒房间， mediodoral thalamic 原子核，和小脑 Purkinje 房间层。用 aP19 房间模型，我们也发现 LRRC4 参予神经原和神经胶质房间的区别。另外，两个都包含一个 LRR 盒子的细胞外的蛋白质和免疫球蛋白领域被显示了参予轴突指导。我们从神经突长出试金的数据显示 LRRC4 支持了海马趾的神经原的神经突扩展，并且导致了 glioblastoma U251 房间的区别进像星形细胞的房间，由形态学观察和 glialfibrillary 证实了酸的蛋白质表示。

英文摘要：

LRRC4, leucine-rich repeat C4 protein, has been identified in human （GenBank accession No. AF196976）, mouse （GenBank accession No. DQ177325）, rat （GenBank accession No. DQ119102） and bovine （GenBank accession No. DQ 164537） with identical domains. In terms of their similarity, the genes encoding LRRC4 in these four mammalian species are orthogs and therefore correspond to the same gene entity. Based on previous research, and using in situ hybridization, we found that LRRC4 had the strongest expression in hippocampal CA1 and CA2, the granule cells of the dentate gyrus region, the mediodoral thalamic nucleus, and cerebella Purkinje cell layers. Using a P19 cell model, we also found that LRRC4 participates in the differentiation of neuron and glia cells. In addition, extracellular proteins containing both an LRR cassette and immunoglobulin domains have been shown to participate in axon guidance. Our data from neurite outgrowth assays indicated that LRRC4 promoted neurite extension of hippocampal neurons, and induced differentiation of glioblastoma U251 cells into astrocyte-like cells, confirmed by morphology observation and glial fibrillary acidic protein expression.