中文摘要：

以3-溴-5-甲氧基-2（5H）-呋喃酮和伯胺为原料，在均相中用三乙胺作碱性催化剂，可以得到一对非对映异构体（1Z,4E，5Z）-6-N-烷基-6-氮杂-2-氧代-3-氧杂-4-甲氧基-双环[3．1．0]己烷（4）和（1Z,4Z,5Z）-6-N-烷基-6-氮杂-2-氧代-3-氧杂-4-甲氧基-双环[3．1．0]己烷（5）.目标分子4和5经IR，^1HNMR，^13C NMR，EIMS进行了表征，并做了结肠癌细胞（HCT-8）、肝癌细胞（BEL-7402）、人胃癌细胞（BGC-823）、肺腺癌细胞（A549）和人卵巢癌细胞（A2780）的抗癌活性实验，其中5c和5d对HCT-8，BGC-823，A549和A2780等癌细胞有一定的抑制作用．此研究结果不仅丰富了该领域研究的理论基础，而且对某些新型药物的研制具有一定的指导意义．

英文摘要：

Pairs of racemic diastereoisomeric aziridine derivatives （4 and 5） were obtained in good yields by Michael addition followed by internal nucleophilic substitution of 3-bromo-5-methoxy-2（SH）-furanone and primary amines. The resulting aziridines were elucidated by IR, ^1H NMR, ^13C NMR and ELMS, and tested for human cancer cell lines including colon cancer （HCT-8）, liver cancer （BEL-7402）, gastric cancer （BGC-823）, pulmonary gland cancer （A549）, and ovary cancer （A2780）, wherein 5c and 5d display good activities against HCT-8, BGC-823, A549 and A2780. This result not only enriches the theoretical basis in this field, but also has a certain guidable significance for the manufacture of some new drugs.