舍格伦综合征(SS)是一种主要累及泪腺和唾液腺等外分泌腺的系统性自身免疫性疾病,分为原发性舍格伦综合征(pSS)和继发性舍格伦综合征(sSS)。辅助性T(Th)细胞中Th1与Th2细胞分化不平衡,Th17细胞与Treg细胞免疫失衡可能对pSS的发生及其发展产生影响。Th细胞分泌的白细胞介素(IL)-6、IL-17、IL-21和IL-23等细胞因子在pSS发病过程中和介导SS小腺体内炎症的过程中可能起着重要的作用。其中,有关Th17细胞及其分泌的细胞因子的研究,可为pSS的治疗提供更为有力和关键的证据。
Sjogren syndrome(SS) is an autoimmune disease that always involves the lacrimal gland and salivary gland exocrine glands, divided into primary SS(pSS) and secondary SS(sSS). Unlike T helper(Th) cells(Thl and Th2 cells) imbalance, Th17 cell and Treg cell immune imbalance may have an impact on the occurrence and development of pSS. Zh cell secretes interleukin(IL)-6, IL-17, IL-21, and IL-23 and may play an important role in the development of the pSS and the inflammation-mediated in vivo SS glandulous. The study of Th17 cell and its secretion of cytokines can provide powerful and critical evidence for the treatment ofpSS in the future.