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中文摘要：
研究了用微流控芯片非接触式电导法分离检测感冒药日夜百服咛片中的两种主要成分盐酸伪麻黄碱和氢溴酸右美沙芬的方法。优化条件为：缓冲液加mmol／LTris＋20mmol／LH3803（pH=8．0）；进样电压300V；进样时间10．0s；分离电压3．0kV。非接触电导检测器激发电压60V（Vp-p），频率60kHz。两种成分的线性范围分别为20-1000mg／L和10-1000mg／L；检出限分别为10和5．0mg／L；样品回收率分别为99．3％和97．6％。
英文摘要：
A method was established for the determination of pseudoephedrine hydrochloride and dextrometho- rphan hydrobromide in Bufferin Cold Tablet by micro-fluidic chip with contacfless conductivity detection. The electrophoretic parameters, such as the variety and concentration of buffer solution, separation voltage etc. were researched. Pseudoephedrine hydrochloride and dextromethorphan hydrobromide in the Bufferin-Cold Tablet were separated in buffer of 20 mmol/L Tris ＋ 20 mmol/L H3 BO3 （ pH 8.0） at 3.0 kV of constant voltage, and detected at frequency of 60 kHz and excitation voltage of 60 V（Vp-p）. The linear concentrations of pseudoephedrine hydrochloride and dextromethorphan hydrobromide ranged from 20 mg/L to 1000 mg/L （r = 0. 999 ） and from 10 mg/L to 1000 mg/L （r = 0. 998 ）, respectively, the limits of detection （LOD） reached 10 mg/L and 5.0 mg/L （ S/N = 3 ）, respectively. The average recoveries were 99.3% （ RSD = 1.4%, n = 6） and 97.6% （ RSD = 1.9% , n = 6） , respectively. The method was rapid, effective, simple and sensitive ; it could be used in the quality control of the product.
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A glass/PDMS hybrid microfluidic chip embedded with integrated electrodes for contactless conductivi
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