中文摘要：

目的 探讨基质金属蛋白酶-2（MMP-2）在血清中的表达与星形细胞瘤预后的关系.方法 随机选取46例经病理证实的星形细胞瘤患者,分为两组：A组为星形细胞瘤Ⅰ～Ⅱ级,B组为星形细胞瘤Ⅲ～Ⅳ级.分别对比两组患者术前,术后3、6、12个月的血清中MMP-2的含量,观察两组患者术前的差异以及复发前后之间的变化.结果 低级别星形细胞瘤术后血清中MMP-2水平为（9.7 ±3.1）g/L,高级别星形细胞瘤术后复发血清中MMP-2水平为（276.0 ±21.0）g/L,差异有统计学意义（P＜0.01）.结论 MMP-2在血清中的表达与星形细胞瘤术后复发密切相关.

英文摘要：

Objective The aim of this article is to discuss the relationship of Expression of matrix metalloproteinase 2 （MMP-2） in blood serum and prognostic of astrocytoma.Methods 46 patients sufferd from astrocytoma are devided into 2 groups：group A contains patients of astrocytoma of grade Ⅰ-Ⅱ ; group B of grade Ⅲ-Ⅳ.The serum total level of MMP-2 are detected separately before surgery and in the 3rd,6th,12th month after surgery.Results Serum MMP-2 level in low grade Astrocytoma was （9.7 ± 3.1） g/L,serum MMP-2 level in high grade Astrocytoma Postoperative recurrence was （276.0 ± 21.0） g/L.The Expression was significant （P ＜ 0.0l）.Conclusion Expression of MMP-2 in blood serum is closely related to the grade and postoperative recurrence of astrocytoma.