中文摘要：

[目的]观察老年患者围术期血浆去甲肾上腺素（NE）和皮质醇（ Cor）水平变化,探讨其与术后认知功能障碍（POCD）的关系.[方法]选择年龄≥60岁、全麻下择期行腹部手术患者60例,于麻醉诱导前5 min（T0）、手术开始后30 min（T1）、手术结束时（T2）、术后24 h（T3） 、术后48 h（T4）测定血浆NE和Cor水平;并评定术前及术后1 d的认知功能;对POCD组和未发生认知功能障碍（NPCD）组手术前后血浆NE和Cor水平变化进行比较.[结果]60例患者血浆NE在T1、T2时升高,血浆Cor 在T1、T2、T3时升高;60例老年患者腹部手术后1 d有13例发生POCD;POCD组血浆NE在T2时高于NPCD组,T2、T3时血浆Cor高于NPCD组.[结论]老年患者术后认知功能障碍发生与围术期血浆NE和Cor变化有密切关系.

英文摘要：

[Objective] To observe the changes of plasma norepinephrine（NE） and corticosteroid（Cor） concentration in elderly patients in perioperative period and explore their relationship with postoperative cognitive dysfunction（POCD）. [Methods] Sixty patients more than 60 years old undergoing elective abdominal surgery were chosen. Plasma NE and Cor were measured at 5min before anesthesia induction（T0）, 30min after the beginning of surgery（T1 ）, at the end of surgery（T2 ）, 24h after surgery（T3 ） and 48h after surgery（T4 ）. POCD was evaluated. Plasma NSE and Cor concentration before and after surgery were compared between POCD group and non-POCD group. [Results] In all 60 patients, plasma NE level increased at T1 and T2, and plasma Cor increased at T1 , T2 and T2. POCD occurred in 13 patients of all 60 elderly patients 1d after abdominal surgery. Plasma NE level at T2 in POCD group was higher than that in non-POCD group. Plasma Cor level at T2 and T3 in POCD group was higher than that in non-POCD group. [Conclusion] POCD in elderly patients is closely related to the levels of plasma NE and Cor in perioperative period.