中文摘要：

目的：研究口服榄香烯微乳在大鼠体内的相对生物利用度。方法：大鼠口服给予榄香烯微乳、榄香烯乳剂后,在不同时间点采血,采用超快速液相色谱法检测血浆榄香烯的浓度,计算其药动学参数与相对生物利用度。结果：榄香烯微乳粒径为（67±13）nm;Zeta电位为（3.2±0.4）mv;pH值为5.16;粘度为6 mpa.s;表面张力为31.7 mN.m-1。榄香烯微乳中β-榄香烯含量为（8.273±0.018）mg.mL-1。榄香烯微乳相对生物利用度为163.1%。结论：大鼠口服榄香烯微乳与榄香烯口服乳相比其生物利用度有较大提高。

英文摘要：

Objective： To study the relative bioavailability of an elemene oral microemulsion on rats in vivo.Methods： After oral administration of elemene microemulsion and emulsion,blood was taken out from rats at different time.Plasma concentration of elemene was detected by ultra-fast liquid chromatography to calculate its pharmacokinetics parameters and relative bioavailability.Results： The elemene microemulsion was characterized as（67±13） nm in size,（3.2 ±0.4） mv in zeta potential,5.16 in pH,6 mpa·s in viscosity,31.7 mN·m-1 in surface tension,（8.273 ±0.018） mg·mL-1 in content of β-elemene.The relative bioavailability of elemene microemulsion was 163.1%.Conclusion： The relative bioavailability of elemene microemulsion is higher than that of elemene emulsion.