脂肪组织来源间充质干细胞(adipose tissue—derived stem cells,ADSCs)因储量丰富、获取简便、扩增迅速、可被诱导多向分化、免疫原性低等诸多优点受到广泛关注,为多种疾病的治疗提供了新思路。肥胖及其相关疾病的发生率日益上升,严重影响人类的生存质量。ADSCs在肥胖的发生和发展过程中起着不可忽视的作用。该文着重对近十年ADSCs的生物学特性研究进展及其在肥胖发生与发展中的作用进行综述,为其早日应用于临床实践提供参考。
Adipose tissue-derived stem cells (ADSCs) provide a promising future for the therapy of multiple diseases due to their abundance, easy of availability, low immunogenicity, huge potential of proliferation and multilineage differentiation abilities. The relationship between ADSCs and obesity is becoming the focus of the public due to the epidemic of obesity and ADSCs connection with it. The current review focuses on the latest research progresses about ADSCs biological characteristics and their correlation with obesity, aiming at provid- ing a theoretical reference for their future application in clinical practice.